Effect of intraoperative irrigation with alteplase on adhesion formation associated with intraperitoneal chemotherapy (experimental study)

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dc.authorwosidÇelik, Hüsnü/AAL-1923-2021
dc.contributor.authorMeydanli, M. M.
dc.contributor.authorCelik, H.
dc.contributor.authorHanay, F.
dc.contributor.authorNalbant, M.
dc.date.accessioned2024-08-04T20:30:56Z
dc.date.available2024-08-04T20:30:56Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To examine the efficacy of intraoperative irrigation with alteplase, a tissue plasminogen activator, for the prevention of adhesion formation associated with intraperitoneal chemotherapy. Material and Methods: Rats, in which serosal injury was induced in the right uterine horn and ipsilateral parietal peritoneum, were randomly divided into four groups. Group I (n = 10) had intraoperative intraperitoneal irrigation with alteplase following the standard operation. Group 11 (n = 10) had irrigation with normal saline, while the rats in Group III (n = 10) and Group IV received no peritoneal irrigation. All rats, except for those in Group IV, received intraperitoneal (IP) paclitaxel plus carboplatin chemotherapy on the seventh postoperative day, and all rats were sacrificed seven days after chemotherapy. Total adhesion scores in the induced standard defects were calculated by evaluating percentage of adhesion formation, as well as the severity and degree of the adhesions. The scores were compared among the groups. Results: Comparison of the severity, percentage, degree and total score of adhesions among the groups demonstrated that subjects in Group 1, where intraoperative alteplase irrigation was used, had fewer adhesion components (severity, percentage, degree) and a lower total adhesion score when compared to the other groups (p < 0.05). Adhesion components and the total adhesion score in Group IV, which did not receive chemotherapy, were found to be significantly lower when compared to Groups 11 and III (p < 0.05). Conclusion: Intraoperative Alteplase irrigation may reduce adhesion formation associated with intraperitoneal chemotherapy. Thus, intraperitoncal chemotherapeutic agents may be ensured to reach all peritoneal surfaces easily.en_US
dc.identifier.endpage389en_US
dc.identifier.issn0392-2936
dc.identifier.issue4en_US
dc.identifier.pmid18714576en_US
dc.identifier.scopus2-s2.0-47949110305en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage386en_US
dc.identifier.urihttps://hdl.handle.net/11616/94599
dc.identifier.volume29en_US
dc.identifier.wosWOS:000257220000017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectintraperitoneal chemotherapyen_US
dc.subjectadhesion formationen_US
dc.subjectpaclitaxelen_US
dc.subjectcarboplatinen_US
dc.subjectalteplaseen_US
dc.titleEffect of intraoperative irrigation with alteplase on adhesion formation associated with intraperitoneal chemotherapy (experimental study)en_US
dc.typeArticleen_US

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