Fibroblast growth factor receptor 1 gene (FGFR1) expression in serous ovarian tumors

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dc.contributor.authorAlan, Saadet
dc.contributor.authorOzcan, Mehmet
dc.date.accessioned2026-04-04T13:14:39Z
dc.date.available2026-04-04T13:14:39Z
dc.date.issued2024
dc.departmentİnönü Üniversitesi
dc.description.abstractAim: The aim of this study was to evaluate the ovarian serous surface epithelial tumors in terms of FGFR1 expression and to evaluate the differences in expression of serous cystadenomas, borderline serous tumor/atypical proliferative serous tumors, low-grade and high-grade serous carcinomas. Materials and Methods: A hundred patients diagnosed with serous cystadenomas, borderline serous tumor/atypical proliferative serous tumors (BST), low-grade (LGSOC) and high-grade serous ovarian carcinomas (HGSOC) between 2010-2020 in our pathology laboratory were included in the study. In these cases, real-time PCR and immunohistochemistry were performed on sections from paraffin blocks. Results: In our study, it was determined that FGFR1 gene expression was statistically significantly increased in HGSOC cases compared to the BST/ LGSOC group and the SC group. Although there was a difference between the BST/ LGSOC group and the SC group, no statistical significance was found. Conclusion: FGFR1 expression was significantly increased in HGSOC cases. This finding has led to the conclusion that angiogenesis inhibition by FGFR inhibition may be a treatment option in HGSOC cases.
dc.identifier.doi10.5455/annalsmedres.2024.01.015
dc.identifier.endpage870
dc.identifier.issn2636-7688
dc.identifier.issue11
dc.identifier.startpage865
dc.identifier.trdizinid1282880
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2024.01.015
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1282880
dc.identifier.urihttps://hdl.handle.net/11616/107375
dc.identifier.volume31
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250329
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectOnkoloji
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.titleFibroblast growth factor receptor 1 gene (FGFR1) expression in serous ovarian tumors
dc.typeArticle

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