Beneficial Effects of Aminoguanidine on Skin Flap Survival in Diabetic Rats

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468;
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidFirat, Cemal/D-1292-2012
dc.contributor.authorOzturk, Ayse
dc.contributor.authorFirat, Cemal
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorBay-Karabulut, Aysun
dc.contributor.authorKirimlioglu, Hale
dc.contributor.authorGurlek, Ali
dc.date.accessioned2024-08-04T20:37:23Z
dc.date.available2024-08-04T20:37:23Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRandom flaps in DM patients have poor reliability for wound coverage, and flap loss remains a complex challenge. The protective effects of aminoguanidine (AG) administration on the survival of dorsal random flaps and oxidative stress were studied in diabetic rats. Two months after the onset of DM, dorsal McFarlane flaps were raised. Forty rats were divided into four groups: (1) control, (2) AG, (3) DM, and (4) DM + AG groups. Flap viability, determined with the planimetricmethod, and free-radical measurements were investigated. In addition, HbA1c and blood glucose levels, body weight measurements, and histopathological examinations were evaluated. The mean flap necrotic areas (%) in Groups I to IV were 50.9 +/- 13.0, 32.9 +/- 12.5, 65.2 +/- 11.5, and 43.5 +/- 14.7, respectively. The malondialdehyde (MDA) and nitric oxide (NO) levels were higher in the DM group than in the nondiabetic group, while the reduced glutathione (GSH) levels and superoxide dismutase (SOD) activity were reduced as a result of flap injury. In the diabetic and nondiabetic groups, AG administration significantly reduced the MDA and NO levels and significantly increased GSH content and SOD enzyme activity. We concluded that AG plays an important role in preventing random pattern flap necrosis.en_US
dc.description.sponsorshipProject Office of Scientific Investigation of Inonu University [2004/02]en_US
dc.description.sponsorshipThis study was supported by the Project Office of Scientific Investigation of Inonu University with Project no. 2004/02. The authors would like to thank all the staff of the Inonu University Animal Research Laboratory for assistance.en_US
dc.identifier.doi10.1155/2012/721256
dc.identifier.issn1687-5214
dc.identifier.pmid23304118en_US
dc.identifier.scopus2-s2.0-84872153474en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1155/2012/721256
dc.identifier.urihttps://hdl.handle.net/11616/95914
dc.identifier.wosWOS:000312828600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofExperimental Diabetes Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectOxidative Stressen_US
dc.subjectBlood-Flowen_US
dc.subjectInhibitionen_US
dc.subjectGlycationen_US
dc.subjectComplicationsen_US
dc.subjectAngiogenesisen_US
dc.subjectDysfunctionen_US
dc.subjectGuanidinesen_US
dc.titleBeneficial Effects of Aminoguanidine on Skin Flap Survival in Diabetic Ratsen_US
dc.typeArticleen_US

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