Activation of the Mas receptors by AVE0991 and MrgD receptor using alamandine to limit the deleterious effects of Ang II-induced hypertension

Basit Öğe Kaydı
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridUlu, Ahmet/0000-0002-4447-6233
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidUlu, Ahmet/L-5180-2016
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.contributor.authorTanriverdi, Lokman Hekim
dc.contributor.authorOzhan, Onural
dc.contributor.authorUlu, Ahmet
dc.contributor.authorYildiz, Azibe
dc.contributor.authorAtes, Burhan
dc.contributor.authorVardi, Nigar
dc.contributor.authorAcet, Haci Ahmet
dc.date.accessioned2024-08-04T20:53:02Z
dc.date.available2024-08-04T20:53:02Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe MrgD receptor agonist, alamandine (ALA) and Mas receptor agonist, AVE0991 have recently been identified as protective components of the renin-angiotensin system. We evaluated the effects of ALA and AVE0991 on cardiovascular function and remodeling in angiotensin (Ang) II-induced hypertension in rats. Sprague Dawley rats were subject to 4-week subcutaneous infusions of Ang II (80 ng/kg/min) or saline after which they were treated with ALA (50 mu g/kg), AVE0991 (576 mu g/kg), or ALA+AVE0991 during the last 2 weeks. Systolic blood pressure (SBP) and heart rate (HR) values were recorded with tail-cuff plethysmography at 1, 15, and 29 days post-treatment. After euthanization, the heart and thoracic aorta were removed for further analysis and vascular responses. SBP significantly increased in the Ang II group when compared to the control group. Furthermore, Ang II also caused an increase in cardiac and aortic cyclophilin-A (CYP-A), monocyte chemoattractant protein-1 (MCP-1), and cardiomyocyte degeneration but produced a decrease in vascular relaxation. HR, matrix metalloproteinase-2 and -9, NADPH oxidase-4, and lysyl oxidase levels were comparable among groups. ALA, AVE0991, and the drug combination produced antihypertensive effects and alleviated vascular responses. The inflammatory and oxidative stress related to cardiac MCP-1 and CYP-A levels decreased in the Ang II+ALA+AVE0991 group. Vascular but not cardiac angiotensin-converting enzyme-2 levels decreased with Ang II administration but were similar to the Ang II+ALA+AVE0991 group. Our experimental data showed the combination of ALA and AVE0991 was found beneficial in Ang II-induced hypertension in rats by reducing SBP, oxidative stress, inflammation, and improving vascular responses.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [TCD-2020-2172]en_US
dc.description.sponsorshipThis study is financially supported by Inonu University Scientific Research Projects Unit (Project no: TCD-2020-2172).en_US
dc.identifier.doi10.1111/fcp.12829
dc.identifier.endpage74en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue1en_US
dc.identifier.pmid36117326en_US
dc.identifier.scopus2-s2.0-85138691876en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage60en_US
dc.identifier.urihttps://doi.org/10.1111/fcp.12829
dc.identifier.urihttps://hdl.handle.net/11616/100909
dc.identifier.volume37en_US
dc.identifier.wosWOS:000859025600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalamandineen_US
dc.subjectangiotensin IIen_US
dc.subjectAVE0991en_US
dc.subjectcyclophilin Aen_US
dc.subjecthypertensionen_US
dc.subjectNADPH oxidaseen_US
dc.titleActivation of the Mas receptors by AVE0991 and MrgD receptor using alamandine to limit the deleterious effects of Ang II-induced hypertensionen_US
dc.typeArticleen_US

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