Protective effect of resveratrol, a red wine constituent polyphenol, on rats subjected to portal vein thrombosis

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dc.authoridTürkoğlu, Suna/0000-0003-4805-1918
dc.authoridHaberal, Mehmet/0000-0002-3462-7632
dc.authorwosidTürkoğlu, Suna/AAJ-2243-2021
dc.authorwosidHaberal, Mehmet/AAJ-8097-2021
dc.contributor.authorKirimlioglu, V.
dc.contributor.authorSozen, H.
dc.contributor.authorTurkoglu, S.
dc.contributor.authorHaberal, M.
dc.date.accessioned2024-08-04T20:30:40Z
dc.date.available2024-08-04T20:30:40Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.descriptionAnnual Meeting of the Turkish-Transplantation-Society -- JUL 04-06, 2007 -- Ankara, TURKEYen_US
dc.description.abstractThis experimental study investigated the prophylactic effects of the antioxidant and antiaggregant compound resveratrol (R) on portal vein thrombosis (PVT) in rats. Thirty rats weighing 200-250 g were distributed in 3 groups: Group A (n = 10) and underwent PVT+R, Group B (n = 10) PVT alone, and Group C (n = 10) were subjected to a sham operation. Group A rats received R (60 mg/d per naso-gastric tube) for 10 days before PVT. Concerning antioxidant status, statistically significant increases in both tissue and plasma levels of reduced glutathione (GSH) and decrease in malondialdehyde (MDA) levels were observed in the PVT+R group compared with the PVT group (P < .001 for all). Comparison of these parameters with those of the sham group revealed significantly higher tissue and plasma levels of GSH and low MDA levels among the sham-operated group when compared with to the PVT+R or PVT groups (P < .001 for all). Concerning the antiaggregant status, significant increases of c-AMP levels were detected in rats treated with R before experiencing PVT (P < .001). Cyclic AMP levels in the sham group were significantly higher than those of either the PVT or PVT+R groups (P < .001). One may advise patients undergoing liver transplantation and carrying certain cardiovascular disease risk factors to ingest foods containing R to minimize PVT.en_US
dc.description.sponsorshipTurkish Transplantat Socen_US
dc.identifier.doi10.1016/j.transproceed.2007.11.051
dc.identifier.endpage292en_US
dc.identifier.issn0041-1345
dc.identifier.issue1en_US
dc.identifier.pmid18261608en_US
dc.identifier.scopus2-s2.0-38749149541en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage290en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2007.11.051
dc.identifier.urihttps://hdl.handle.net/11616/94447
dc.identifier.volume40en_US
dc.identifier.wosWOS:000253229500074en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOrthotopic Liver-Transplantationen_US
dc.subjectPlatelet-Aggregationen_US
dc.subjectIn-Vitroen_US
dc.subjectManagementen_US
dc.titleProtective effect of resveratrol, a red wine constituent polyphenol, on rats subjected to portal vein thrombosisen_US
dc.typeConference Objecten_US

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