Proteolytic enzyme sensitivity and decrease in respiratory function (a 10-year follow-up)

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dc.authoridHacievliyagil, Suleyman Savas/0000-0002-2572-1870
dc.authoridGunen, Hakan/0000-0001-6631-4457
dc.authorwosidHacievliyagil, Suleyman Savas/ABI-7307-2020
dc.authorwosidGunen, Hakan/HKV-9202-2023
dc.contributor.authorKizkin, O
dc.contributor.authorSuleyman, GT
dc.contributor.authorHacievliyagil, S
dc.contributor.authorGunen, H
dc.date.accessioned2024-08-04T20:13:09Z
dc.date.available2024-08-04T20:13:09Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: In workers, sensitivity and occupational asthma are known to develop in reaction to the proteolytic enzymes used in the manufacture of detergents. This study was conducted to find out how this sensitivity to the proteolytic enzymes affects respiratory function, excluding occupational asthma. Methods: Workers in the detergent industry (n = 65) were divided into four groups according to their prick-test results, as follows: those positive for at least one enzyme (Lipolase, Savinase) (group I, n = 15); enzyme-negative cases (group II, n = 50); and from among these, enzyme-positive non-smoking cases (group Ia, n = 11); enzyme-negative non-smoking cases (group IIa, n = 32) Respiratory function tests for the last 10 years from the archives were assessed. For statistic analysis, average values were determined and the standard deviation calculated. For comparison of the groups, the Mann-Whitney U and Fischer Exact chi-square tests were used. Results: The ratio of smokers, the cigarette burden, average age and the period of work were found to be similar between workers of groups I and II, and group Ia and group IIa (P>0.05). The average annual fall in the forced vital capacity (FVC) and the forced expiratory volume in the first second (FEV1) for the 10-year period was, respectively, found to be: group I, 64.1 +/- 7.8 ml and 58.7 +/- 9.6 ml; group II, 38.7 +/- 6.4 ml and 43.7 +/- 18.2 ml; group Ia, 60.7 +/- 8.1 ml and 56.1 +/- 10.2 ml; group IIa, 37.4 +/- 6.8 ml and 42.9 +/- 8.1 ml. The decrease in FVC and FEV1 in group I compared with group II, and in group Ia compared with group IIa was statistically significant (P<0.001). Conclusions: In this study, the observation that the FVC and FEV1 of the workers were much lower than expected, especially among those sensitive to the enzymes, independently of occupational asthma and cigarette smoking, led to the conclusion that it could be due to sensitivity to the enzymes.en_US
dc.identifier.doi10.1007/s00420-002-0326-4
dc.identifier.endpage444en_US
dc.identifier.issn0340-0131
dc.identifier.issn1432-1246
dc.identifier.issue6en_US
dc.identifier.pmid12070641en_US
dc.identifier.scopus2-s2.0-0036705629en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage441en_US
dc.identifier.urihttps://doi.org/10.1007/s00420-002-0326-4
dc.identifier.urihttps://hdl.handle.net/11616/93431
dc.identifier.volume75en_US
dc.identifier.wosWOS:000177175900010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Archives of Occupational and Environmental Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectproteolytic enzymeen_US
dc.subjectrespiratory function testen_US
dc.subjectprick testen_US
dc.titleProteolytic enzyme sensitivity and decrease in respiratory function (a 10-year follow-up)en_US
dc.typeArticleen_US

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