Propofol’un immun sisteme etkisinin tiyopental ile karşılaştırılması
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Dosyalar
Tarih
1997
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi Tıp Fakültesi Dergisi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Çalışmamızda, propofol ve tiyopental'in immünolojik etkilerinin karşılaştırılması amaçlanmıştır. Total intravenöz anestezi (TIVA) tekniğiyle birinci gruptaki hastalara propofol infüzyonu, ikinci gruptakilere ise tiyopental uygulandı. Hastalardan operasyondan 30 dk önce, 30 dk ve 24 saat sonra alınan kanlarda immünolojik ve hematolojik tetkikler yapıldı. Ayrıca hastalara anestezi indüksiyonundan 2 gün önce ve sonra tüberkülin testi uygulandı. Çalışmamız sonucunda, 1. grupta postoperatif 30. dk'da IgG, IgM, IgA ve C3, ikinci grupta ise IgM, IgA ve C4 düzeylerindeki azalma anlamlı bulundu (p<0.05). Postoperatif 24. saatte 1. grupta IgG, IgM ve C3 'teki artma ile IgA 'daki azalma, 2. grupta ise IgA 'daki azalma anlamlı idi (p<0.05). Gruplar arası fark karşılaştırıldığında postoperatif 30. dk ile 24. saat arasında IgA'daki azalmanın farkları anlamlı bulundu (p<0.05). Her iki grupta da CD4, lökosit ve lenfositdeki azalma anlamlı idi (p<0.05). Postoperatif 24. saatte CD4, CD8 ve lenfosit değerleri 1. grupta anlamlı artarken 2. grupta sadece lenfosit artımı anlamlı bulundu (p<0.05). Gruplar arası fark araştırıldığında 1. gruptaki lökosit ve lenfosit değerlerindeki azalma anlamlı idi (p<0.05). Tüberkülin testi postop. 2. gün ölçüm sonuçlarının her iki grupta da anlamlı derecede azaldığı görüldü (p<0.05). Propofolün daha belirgin olmak üzere her iki ajanın da immunsüpresif etkisi olduğu tespit edildi.
This study was designed to compare the immunological effect of thiopentone with propofol. By using TIVA technique first group patients were infused with propofol and second group infused with thiopentone. Many immunological and haematological tests were studied on samples obtained 30 min. before, 30 min. and 24 hr after the operation. The PPD test was also implemented before and after two days of anaesthesia. In the study at postoperative 30h min. decrease of IgG, IgM, IgA and C3 in the group used propofol and decrease of IgM, IgA and C4 in the group used thiopentone were significant (p<0.05). At postoperative 24th hours increases of the IgG, IgM, and C3 levels and decrease of IgA level in the first group and decrease of the IgA level in second group were significant (p<0.05). When compared the difference between the groups, difference of the decrease in the IgA level was significant (p<0.05). In the both groups, decreases of CD4, leucocyte and lymphocyte were significant (p<0.05). At postoperative 24th hours while CD4 and CD8 levels and lymphocyte counts were significantly increasing in the first group, just lymphocyte count increase was significant in the second group (p<0.05). When compared the difference between the groups, decreases of the leucocyte and lymphocyte counts in the first group were significant (p<0.05). The postoperative second days PPD results were significantly decreased in both group (p<0.05). We concluded that both agents especially propofol have an immunosuppressive effect.
This study was designed to compare the immunological effect of thiopentone with propofol. By using TIVA technique first group patients were infused with propofol and second group infused with thiopentone. Many immunological and haematological tests were studied on samples obtained 30 min. before, 30 min. and 24 hr after the operation. The PPD test was also implemented before and after two days of anaesthesia. In the study at postoperative 30h min. decrease of IgG, IgM, IgA and C3 in the group used propofol and decrease of IgM, IgA and C4 in the group used thiopentone were significant (p<0.05). At postoperative 24th hours increases of the IgG, IgM, and C3 levels and decrease of IgA level in the first group and decrease of the IgA level in second group were significant (p<0.05). When compared the difference between the groups, difference of the decrease in the IgA level was significant (p<0.05). In the both groups, decreases of CD4, leucocyte and lymphocyte were significant (p<0.05). At postoperative 24th hours while CD4 and CD8 levels and lymphocyte counts were significantly increasing in the first group, just lymphocyte count increase was significant in the second group (p<0.05). When compared the difference between the groups, decreases of the leucocyte and lymphocyte counts in the first group were significant (p<0.05). The postoperative second days PPD results were significantly decreased in both group (p<0.05). We concluded that both agents especially propofol have an immunosuppressive effect.
Açıklama
[Journal of Turgut Özal Medical Center 1997;4(2):187-192]
Anahtar Kelimeler
Propofol, Tiyopental, İmmun sistem, Immune system, Thiopentone
Kaynak
Turgut Özal Tıp Merkezi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
4
Sayı
2
Künye
Altındiş, M.,Altındiş, M.,Ali, K.,Celalettin, V., A. Zeki, Ş.,(1997). Propofol’un immun sisteme etkisinin tiyopental ile karşılaştırılması.Turgut Özal Tıp Merkezi Dergisi, 4 (2).187-192 ss.
