Evaluation of Pharmacokinetics and Biodistribution of Targeted Nanoparticles

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dc.authorscopusid56960016500
dc.authorscopusid57194390086
dc.authorscopusid57572679000
dc.authorscopusid36717717200
dc.authorscopusid57221923900
dc.contributor.authorAtes M.
dc.contributor.authorIzat N.
dc.contributor.authorKir F.
dc.contributor.authorGulsun T.
dc.contributor.authorSahin S.
dc.date.accessioned2024-08-04T20:04:02Z
dc.date.available2024-08-04T20:04:02Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNanotechnology attracts more attention day by day in the field of pharmacy as in many fields. This chapter discusses the biodistribution and pharmacokinetic (PK) properties of nanoparticles, the factors affecting these properties, and studies for assessment. Physiologically based pharmacokinetic modeling (PBPK) is a powerful descriptive tool that mechanistically describes the PK and/or pharmacodynamic behaviors of drugs by using models and simulations with combined considerations of physiology, population, and drug characteristics. The chapter highlights PBPK applications for the PK evaluation and formulation development of nanoparticles. PBPK models are valuable tools to understand and predict the in vivo reflection of changes in formulation design and development factors. Using the dissolution- and distribution-based model, the observed in vivo situation was described successfully by establishing an in vitro–in vivo correlation between physicochemical characteristics of the formulation and clinical data. © 2022 Jenny Stanford Publishing Pte. Ltd.en_US
dc.identifier.doi10.1201/9781003164739-14
dc.identifier.endpage379en_US
dc.identifier.isbn9781000375268
dc.identifier.isbn9789814877756
dc.identifier.scopus2-s2.0-85128108836en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage345en_US
dc.identifier.urihttps://doi.org/10.1201/9781003164739-14
dc.identifier.urihttps://hdl.handle.net/11616/92310
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofDrug Delivery with Targeted Nanoparticles: In Vitro and in Vivo Evaluation Methodsen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEvaluation of Pharmacokinetics and Biodistribution of Targeted Nanoparticlesen_US
dc.typeBook Chapteren_US

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