Ameliorative effects of dexpanthenol and/or melatonin application in experimental spinal cord injury

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dc.contributor.authorKorkmaz, Mehmet Fatih
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorEroglu, Ahmet
dc.contributor.authorYalcinkaya, Burhanettin
dc.contributor.authorOzer, Omer Faruk
dc.contributor.authorCobanoglu, Bengu
dc.contributor.authorBaysal, Begumhan
dc.date.accessioned2026-04-04T13:33:33Z
dc.date.available2026-04-04T13:33:33Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground and AimsPotential ameliorative effects of melatonin and dexpanthenol alone or in combination were investigated by neurological, histopathological, biochemical, and molecular means in an experimental spinal cord injury model in rats.Methods and ResultsForty-two Sprague Dawley female rats were equally divided into six groups as control (C), sham (S), spinal cord injury (SCI), spinal cord injury with dexpanthenol application (SCI+Dex), spinal cord injury with melatonin application (SCI+Mel), and spinal cord injury with dexpanthenol and melatonin application (SCI+Dex+Mel). In neurochemical analysis, mean Modified Tarlov Scale measurement was significantly better in the SCI+Dex and SCI+Dex+Mel groups as compared to the SCI group at the last measurement point. In biochemical analysis, tissue levels of GSH, SOD, MDA, and XO increased significantly in the SCI group compared to the control. However, no changes were detected among the groups in gene expression levels of XO, SOD, NF-kappa B, and CASP3. Histopathological examination revealed severe neuronal degeneration in the SCI group, while the severity of the lesions decreased in the Mel and/or Dex given groups.ConclusionOverall, the results indicated that Dex+Mel application may have an ameliorative effect on neuroprotection especially at the later stages of spinal cord injury.
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit, Turkiye [TDK-2021-2367]
dc.description.sponsorshipThis work was supported by Inonu University Scientific Research Projects Coordination Unit under Grant number TDK-2021-2367, Turkiye
dc.identifier.doi10.1080/10790268.2025.2580127
dc.identifier.issn1079-0268
dc.identifier.issn2045-7723
dc.identifier.orcid0000-0002-3744-6634
dc.identifier.orcid0000-0002-9034-4805
dc.identifier.orcid0000-0002-3874-633X
dc.identifier.orcid0000-0002-3613-0523
dc.identifier.orcid0000-0001-7498-6763
dc.identifier.orcid0000-0002-8600-0946
dc.identifier.orcid0000-0002-4248-1434
dc.identifier.pmid41358999
dc.identifier.scopus2-s2.0-105024892033
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/10790268.2025.2580127
dc.identifier.urihttps://hdl.handle.net/11616/109248
dc.identifier.wosWOS:001632908100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Spinal Cord Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectSpinal cord injury
dc.subjectdexpanthenol
dc.subjectmelatonin
dc.subjectgene expression
dc.titleAmeliorative effects of dexpanthenol and/or melatonin application in experimental spinal cord injury
dc.typeArticle

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