The effects of caffeic acid phenethyl ester on streptozotocin-induced diabetic liver injury

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridÖzyalın, Fatma/0000-0001-6486-6389
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidÖzyalın, Fatma/ABC-7193-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidElbe, Hulya/D-5261-2015
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorTaslidere, E.
dc.contributor.authorGul, M.
dc.contributor.authorElbe, H.
dc.contributor.authorCetin, A.
dc.contributor.authorVardi, N.
dc.contributor.authorOzyalin, F.
dc.contributor.authorTurkoz, Y.
dc.date.accessioned2024-08-04T20:43:01Z
dc.date.available2024-08-04T20:43:01Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study was to clarify the role of oxidative stress in streptozotocin induced liver injury and the possible protective effect of caffeic acid phenethyl ester (CAPE) using histological and biochemical parameters. 32 male Wistar rats were divided into 4 groups as follows: Group 1: Control animals, Group 2: Control animals given CAPE Group 3: STZ-induced diabetic animals (DM group), Group 4: STZ-induced diabetic rats given CAPE (DM+CAPE group). All the injections started on the same day of single-dose STZ injection and continued for 20 days. At the end of this period, livers were removed and processed for routine histological procedures. Biochemical parameters and morphological changes were examined. In DM group, blood glucose levels were significantly increased compared with the control group. Significant increases in tissue malondialdehyde (MDA) level and decreases in superoxide dismutase (SOD) and total glutathione (GSH) activities were detected in DM group. Administration of CAPE significantly reduced these values. STZ-induced histopathological alterations including inflammatory cell infiltration around portal triad, congestion, loss of glycogen in the hepatocytes. Additionally, degenerative cellular alterations, such as numerous vacuolizations including myelinic figure formation, pyknotic nuclei with peripheral localization of heterochromatin condensation and mitochondria! elongation were observed in cytoplasm of hepatocytes. CAPE significantly reduced these histopathological changes. Our results indicate that CAPE should be considered in the prevention of oxidative stress in diabetic liver (Tab. 3, Fig. 4, Ref. 47). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2016_054
dc.identifier.endpage282en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue5en_US
dc.identifier.pmid27215964en_US
dc.identifier.scopus2-s2.0-85014833403en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage276en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2016_054
dc.identifier.urihttps://hdl.handle.net/11616/97725
dc.identifier.volume117en_US
dc.identifier.wosWOS:000376813300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectstreptozotocinen_US
dc.subjectliveren_US
dc.titleThe effects of caffeic acid phenethyl ester on streptozotocin-induced diabetic liver injuryen_US
dc.typeArticleen_US

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