Increased serum ferritin levels in patients with Crimean-Congo hemorrhagic fever: can it be a new severity criterion?

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dc.authoridBarut, Sener/0000-0003-2047-8573
dc.authoridErkorkmaz, Ünal/0000-0002-8497-4704
dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authoridSahin, Idris/0000-0002-8683-3737
dc.authorwosidBarut, Sener/AAI-2731-2021
dc.authorwosidErkorkmaz, Ünal/AAA-4241-2022
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.authorwosidSahin, Idris/AAS-4390-2020
dc.contributor.authorBarut, Sener
dc.contributor.authorDincer, Fatma
dc.contributor.authorSahin, Idris
dc.contributor.authorOzyurt, Huseyin
dc.contributor.authorAkkus, Mehmet
dc.contributor.authorErkorkmaz, Unal
dc.date.accessioned2024-08-04T20:32:15Z
dc.date.available2024-08-04T20:32:15Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Serum ferritin is one of the markers indicating hemophagocytosis that may have a role in the pathogenesis of Crimean-Congo hemorrhagic fever (CCHF). This study was designed to determine any correlation between serum ferritin and routine diagnostic laboratory markers of CCHF, and to investigate the relationship between serum ferritin levels and disease severity. Methods: Sixty-six patients with CCHF admitted to the hospital during the spring and summer months of 2006 and 2007 were included in the study. Serum ferritin levels were measured in sera obtained during the initial days of hospitalization. Data from 53 patients showing decreasing platelet counts over the first three days were used for further analysis and these patients were divided into two groups according to disease severity: group A included severe cases with lowest platelet counts <= 20 x 10(9)/l and group B included mild cases with lowest platelet counts > 20 x 10(9)/l. Results: Forty patients (60.6%) were male (mean age 43 +/- 17 years). Three patients died, thus the fatality rate was 4.5%. Fifty-one patients (77.3%) had abnormal serum ferritin levels, with levels above 500 ng/ml in 62.1%. There was a significant negative correlation between ferritin levels and concordant platelet counts (p < 0.001; r = -0.416) and ferritin was also found to be positively correlated with aspartate aminotransferase (p < 0.001; r = 0.625), alanine aminotransferase (p < 0.001; r = 0.479), and lactate dehydrogenase (p < 0.001; r = 0.684). Group A had higher ferritin levels than group B (p < 0.001). Receiver operating characteristic analysis revealed that a ferritin level of >= 1862 ng/ml had a sensitivity of 87.5% and a specificity of 83.8% in differentiating severe cases from mild ones. Conclusions: Increased serum ferritin levels may suggest a significant role of hemophagocytosis in the pathogenesis of CCHF and may be a useful marker for diagnosis, disease activity, and prognosis. (C) 2009 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijid.2009.03.009
dc.identifier.endpageE54en_US
dc.identifier.issn1201-9712
dc.identifier.issn1878-3511
dc.identifier.issue1en_US
dc.identifier.pmid19487150en_US
dc.identifier.scopus2-s2.0-74649084140en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE50en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2009.03.009
dc.identifier.urihttps://hdl.handle.net/11616/94957
dc.identifier.volume14en_US
dc.identifier.wosWOS:000273987200008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInternational Journal of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCrimean-Congo hemorrhagic feveren_US
dc.subjectFerritinen_US
dc.subjectHemophagocytosisen_US
dc.subjectPlatelet counten_US
dc.titleIncreased serum ferritin levels in patients with Crimean-Congo hemorrhagic fever: can it be a new severity criterion?en_US
dc.typeArticleen_US

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