Possible bradykinesia occurrence in lymphocyte division in Parkinson's disease

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dc.authorscopusid56543480800
dc.authorscopusid56117158100
dc.authorscopusid57223038605
dc.authorscopusid58971358800
dc.authorscopusid58972636300
dc.authorscopusid57196914953
dc.contributor.authorInalkac Gemici Y.
dc.contributor.authorTasci I.
dc.contributor.authorDundar M.
dc.contributor.authorOzgen N.
dc.contributor.authorGozde Gozukara H.
dc.contributor.authorKoc A.
dc.date.accessioned2024-08-04T20:02:18Z
dc.date.available2024-08-04T20:02:18Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractLymphocytes have dopamine receptors, and low dopamine levels increase receptor synthesis. Lymphocytes may move slower in Parkinson's, which is characterized by low dopamine levels. We hypothesized that longer telomeres would indicate less lymphocyte division. We investigated whether leukocyte telomere length (LTL) is different in naïve Parkinson’s disease (PD) patients and whether telomere length has clinical significance in determining telomere length in naïve Parkinson's patients. Naïve patients diagnosed with PD were included in this study. 29 naïve PD patients and 15 controls were included in the study. Subgroup analyses were performed according to MMSE and depression scores of PD patients. LTL was measured by RT-qPCR. Differences in LTL between the groups were examined. Clinical and demographic findings and LTL were examined and correlated using appropriate statistical methods. Forty-four participants meeting the inclusion criteria were included in the study. LTL was significantly longer in PD patients than in the control group (p = 0.043) and was positively correlated with clinical worsening of the disease. According to the Analysis of Moment Structures, evaluation total MMSE was 1.82, UPDRS was -1.53, and depression score was -.31 negatively correlated with telomere. LTL was found to be longer in naïve PD patients than in controls. Without other factors that could affect telomere; these findings support the hypothesis that leukocyte division could be slower in PD than the control group at the same age. Additional studies are needed on this subject. Additionally, a longer TL could be a marker for a better clinical course in PD. © 2024 Ondokuz Mayis Universitesi. All rights reserved.en_US
dc.identifier.doi10.52142/omujecm.41.1.14
dc.identifier.endpage91en_US
dc.identifier.issn1309-4483
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85189557338en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage86en_US
dc.identifier.urihttps://doi.org/10.52142/omujecm.41.1.14
dc.identifier.urihttps://hdl.handle.net/11616/91589
dc.identifier.volume41en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOndokuz Mayis Universitesien_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiomarkersen_US
dc.subjectcognitive dysfunctionen_US
dc.subjectParkinson's diseaseen_US
dc.subjecttelomeren_US
dc.titlePossible bradykinesia occurrence in lymphocyte division in Parkinson's diseaseen_US
dc.typeArticleen_US

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