Elevated level of plasma homocysteine in patients with slow coronary flow

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dc.contributor.authorErbay, AR
dc.contributor.authorTurhan, H
dc.contributor.authorYasar, AS
dc.contributor.authorAyaz, S
dc.contributor.authorSahin, O
dc.contributor.authorSenen, K
dc.contributor.authorSasmaz, H
dc.date.accessioned2024-08-04T20:40:11Z
dc.date.available2024-08-04T20:40:11Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBack-ground: Elevated plasma levels of homocysteine are currently considered a major, independent risk factor for cardiovascular diseases. Recently, several investigators have Suggested that even mild elevation in plasma homocysteine level can severely disturb vascular endothelial function and subsequently impair coronary blood flow. Accordingly, we investigated plasma homocysteine level in patients with slow coronary flow. Method: Study population included 53 patients with angiographically proven normal coronary arteries and slow coronary flow in all three coronary vessels (group I, 21 females, 32 males, mean age=48 +/- 9 years), and 50 subjects with angiographically proven normal coronary arteries without associated slow coronary flow (group II, 22 females, 28 males, mean age=50 +/- 8 years). Coronary flow rates of all patients and control subjects were documented by Thrombolysis In Myocardial Infarction frame count (TIMI frame count). All patients in group I had TIMI frame counts greater than two standard deviations above those of control subjects (group II) and, therefore, were accepted as exhibiting slow coronary flow. The mean TIMI frame Count for each patient and control subject was calculated by adding the TIMI frame counts for each major epicardial coronary artery and then dividing the obtained value into 3. Plasma homocysteine level was measured in all patients and control subjects using commercially available homocysteine kits. Results: There was no statistically significant difference between two groups in respect to age, gender, hypertension, diabetes mellitus, hyperlipidemia and cigarette smoking (p > 0.05). Plasma homocysteine level of patients with slow coronary flow were found to be significantly higher than those of control subjects (15.5 +/- 5.7 vs. 8.7 +/- 4.2 mu M/l, respectively, p < 0.001). Moreover, we found a significant positive correlation between plasma homocysteine level and mean TIMI frame count (r=0.660, p < 0.001). Conclusion: We have shown that patients with slow coronary flow have raised level of plasma homocysteme compared to control subjects with normal coronary flow. This data suggests that elevated level of plasma homocysteine may play a role in the pathogenesis of slow coronary flow. (c) 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijcard.2004.05.064
dc.identifier.endpage423en_US
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.issue3en_US
dc.identifier.pmid16004886en_US
dc.identifier.scopus2-s2.0-84928485346en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage419en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2004.05.064
dc.identifier.urihttps://hdl.handle.net/11616/96765
dc.identifier.volume102en_US
dc.identifier.wosWOS:000230856200007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthomocysteineen_US
dc.subjectslow coronary flowen_US
dc.subjectendothelial dysfunctionen_US
dc.titleElevated level of plasma homocysteine in patients with slow coronary flowen_US
dc.typeArticleen_US

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