The Investigation of Association Between Il-10- 1082 Polymorphism and Human Papillomavirus Infection in Prostatic Tissue Samples
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Yayincilik
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction: Some studies of prostate cancer (PCa) have reported the presence of human papillomavirus (HPV) DNA. Polymorphisms in IL-10 gene can influence inflammation and immune response and may be related to the risk of prostate cancer. The capacity for IL-10 production varies according to the genetic composition of the IL-10 locus. We aimed to elucidate the relation between HPV infection and IL-10 polymorphism for the development of prostate cancer. We examined 108 formalin-fixed specimens for the existence of HPVs DNA and IL- 10 - 1082 genotype distribution. Materials and Methods: The DNA are extracted from archival prostate tissues of totally 108 patients, 40 of whom with adenocarcinoma and 68 with benign prostatic hyperplasia (BPH). Genotypes of IL- 10 - 1082 single nucleotide polymorphism (SNP) were performed using allele specific polymerase chain reaction (ARMS). HPV detection was performed by using conventional HPV primers. Results: HPVs DNA was detected in 15 of 68 BPH specimens (22%) and in 16 of 40 prostate PCa specimens (40%). Distribution of IL- 10 - 1082 genotype was not statistically different between PCa and BPH using chi-square (p> 0.05). There was not any association between HPVs DNA positivity and IL- 10 - 1082 genotypes. Conclusion: The results suggest that the HPVs DNA positivity might be involved in the etiology of a minority of prostate cancers. As result, we consider that future investigations are needed to provide conclusive evidence on the role of this pathogen and genes in the prostate cancer.
Açıklama
Anahtar Kelimeler
Human papillomavirus, prostatic cancer, benign prostatic hyperplasia, interleukin-10, polymorphism
Kaynak
Mediterranean Journal of Infection Microbes and Antimicrobials
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
1
