The Investigation of Association Between Il-10- 1082 Polymorphism and Human Papillomavirus Infection in Prostatic Tissue Samples

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dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117;
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.authorwosidYarkin, Fugen/J-9476-2018
dc.contributor.authorEtem, Ebru
dc.contributor.authorBulut, Yasemin
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorAskin, Yasemin
dc.contributor.authorElyas, Halit
dc.contributor.authorYarkin, Fugen
dc.date.accessioned2024-08-04T21:02:04Z
dc.date.available2024-08-04T21:02:04Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Some studies of prostate cancer (PCa) have reported the presence of human papillomavirus (HPV) DNA. Polymorphisms in IL-10 gene can influence inflammation and immune response and may be related to the risk of prostate cancer. The capacity for IL-10 production varies according to the genetic composition of the IL-10 locus. We aimed to elucidate the relation between HPV infection and IL-10 polymorphism for the development of prostate cancer. We examined 108 formalin-fixed specimens for the existence of HPVs DNA and IL- 10 - 1082 genotype distribution. Materials and Methods: The DNA are extracted from archival prostate tissues of totally 108 patients, 40 of whom with adenocarcinoma and 68 with benign prostatic hyperplasia (BPH). Genotypes of IL- 10 - 1082 single nucleotide polymorphism (SNP) were performed using allele specific polymerase chain reaction (ARMS). HPV detection was performed by using conventional HPV primers. Results: HPVs DNA was detected in 15 of 68 BPH specimens (22%) and in 16 of 40 prostate PCa specimens (40%). Distribution of IL- 10 - 1082 genotype was not statistically different between PCa and BPH using chi-square (p> 0.05). There was not any association between HPVs DNA positivity and IL- 10 - 1082 genotypes. Conclusion: The results suggest that the HPVs DNA positivity might be involved in the etiology of a minority of prostate cancers. As result, we consider that future investigations are needed to provide conclusive evidence on the role of this pathogen and genes in the prostate cancer.en_US
dc.identifier.issn2147-673X
dc.identifier.urihttps://hdl.handle.net/11616/104462
dc.identifier.volume1en_US
dc.identifier.wosWOS:000219728500006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofMediterranean Journal of Infection Microbes and Antimicrobialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHuman papillomavirusen_US
dc.subjectprostatic canceren_US
dc.subjectbenign prostatic hyperplasiaen_US
dc.subjectinterleukin-10en_US
dc.subjectpolymorphismen_US
dc.titleThe Investigation of Association Between Il-10- 1082 Polymorphism and Human Papillomavirus Infection in Prostatic Tissue Samplesen_US
dc.typeArticleen_US

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