The Relationship between COVID-19 Severity and Bacillus Calmette-Guerin (BCG)/ Mycobacterium tuberculosis exposure history in healthcare workers: a multi-center study

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dc.authoridYOSUNKAYA, ŞEBNEM/0000-0002-7859-8941
dc.authoridErsoy, Yasemin/0000-0001-5730-6682
dc.authoridOZCELIK, Neslihan/0000-0002-4672-6179
dc.authoridKaraman, Irem/0000-0001-7559-9095
dc.authoridKANAT, Fikret/0000-0002-1912-0200
dc.authoridyildirim, berna botan/0000-0001-7730-1379
dc.authoridTorun, Serife/0000-0002-6530-6153
dc.authorwosidYOSUNKAYA, ŞEBNEM/AAQ-5884-2021
dc.authorwosidErsoy, Yasemin/AAE-4811-2020
dc.authorwosidAydogan Eroglu, Selma/GWU-6454-2022
dc.authorwosidOZCELIK, Neslihan/GPF-5216-2022
dc.authorwosidKaraman, Irem/HLW-2801-2023
dc.authorwosidKANAT, Fikret/KGL-1188-2024
dc.authorwosidyildirim, berna botan/AAC-9599-2019
dc.contributor.authorTorun, Serife
dc.contributor.authorOzkaya, Sevket
dc.contributor.authorSen, Nazan
dc.contributor.authorKanat, Fikret
dc.contributor.authorKaraman, Irem
dc.contributor.authorYosunkaya, Sebnem
dc.contributor.authorSengoren Dikis, Ozlem
dc.date.accessioned2024-08-04T20:50:14Z
dc.date.available2024-08-04T20:50:14Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe COVID-19 pandemic has brought countries' health services into sharp focus. It was drawn to our group's attention that healthcare workers (HCWs) had a lower mortality rate against higher COVID-19 incidence compared to the general population in Turkey. Since risk of exposure to tuberculosis bacillus among healthcare workers are higher than the population, we aimed to investigate if there is a relationship between BCG and Mycobacterium tuberculosis exposure history with COVID-19 severity in infected HCWs. This study was conducted with 465 infected HCWs from thirty-three hospitals to assess the relationship between COVID-19 severity (according to their hospitalization status and the presence of radiological pneumonia) and BCG and Mycobacterium tuberculosis exposure history. HCWs who required hospital admission had significantly higher rates of chronic diseases, radiological pneumonia, and longer working hours in the clinics. Higher rates of history of contact and care to tuberculosis patients, history of tuberculosis, and BCG vaccine were observed in hospitalized HCWs. HCWs who had radiological pneumonia had a significantly increased ratio of history of care to tuberculosis patients and a higher family history of tuberculosis. The findings from our study suggest that the lower mortality rate despite the more severe disease course seen in infected HCWs might be due to frequent exposure to tuberculosis bacillus and the mortality-reducing effects of the BCG vaccine.en_US
dc.identifier.doi10.1080/20477724.2021.1927605
dc.identifier.endpage411en_US
dc.identifier.issn2047-7724
dc.identifier.issn2047-7732
dc.identifier.issue6en_US
dc.identifier.pmid34014806en_US
dc.identifier.scopus2-s2.0-85106232474en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage405en_US
dc.identifier.urihttps://doi.org/10.1080/20477724.2021.1927605
dc.identifier.urihttps://hdl.handle.net/11616/99939
dc.identifier.volume115en_US
dc.identifier.wosWOS:000652371400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPathogens and Global Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjecttuberculosisen_US
dc.subjectBCGen_US
dc.subjecthealthcare workersen_US
dc.subjectpneumoniaen_US
dc.subjectmortalityen_US
dc.titleThe Relationship between COVID-19 Severity and Bacillus Calmette-Guerin (BCG)/ Mycobacterium tuberculosis exposure history in healthcare workers: a multi-center studyen_US
dc.typeArticleen_US

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