Gundelia Tournefortii L. (Kenger): Determination of in vitro Antidiabetic Activities

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dc.authoridKeskin, Merve/0000-0001-9365-334X;
dc.authorwosidKeskin, Merve/AAG-4704-2020
dc.authorwosidKESKİN, Şaban/HTP-5432-2023
dc.contributor.authorKeskin, Merve
dc.contributor.authorKaya, Gulsen
dc.contributor.authorKeskin, Saban
dc.date.accessioned2024-08-04T20:51:54Z
dc.date.available2024-08-04T20:51:54Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDiabetes mellitus is a chronic disease that negatively effects daily life. Synthetic drugs, which are inhibitors of alpha-glucosidase and alpha-amylase enzymes, are used in its treatment. These drugs may have adverse reaction on organs such as the liver. Therefore, it is important to include plants that inhibit these enzymes in the diet in the treatment of Diabetes mellitus. Gundelia tournefortii L. (Kenger) is an edible wild natural plant that is widely used as traditional food. In this study, biochemical characterization of the Gundelia tournefortii L. (Kenger) extracts was performed. The inhibition effect of the extract on alpha-amylase and alpha-glycosidase enzymes was also investigated. Total phenolic content, antioxidant activity and chemical composition of Gundelia tourneforti L. extracts were determined. Chemical composition of extracts was determined by using GC/MS technique. IC50 values of alpha-amylase and alpha-glucosidase enzymes of the Gundelia tournefortii L. ethanolic extracts of stalk were determined as 4.18 +/- 0.08 mg/mL and 9.77 +/- 1.2 mg/mL, respectively. The results showed that Gundelia tournefortii L. could be used as a supplementary food in the treatment of Type 2 diabetes.en_US
dc.description.sponsorshipBilecik Seyh Edebali University Scientific Research Project [2019-02, BSEU.12-01]en_US
dc.description.sponsorshipThis work was supported by the Bilecik Seyh Edebali University Scientific Research Project (Project No: 2019-02.BSEU.12-01).en_US
dc.identifier.doi10.23751/pn.v23i4.11079
dc.identifier.issn1129-8723
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85128737720en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.23751/pn.v23i4.11079
dc.identifier.urihttps://hdl.handle.net/11616/100614
dc.identifier.volume23en_US
dc.identifier.wosWOS:000756685000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofProgress in Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGundelia tournefortii Len_US
dc.subjectDiabetes mellitusen_US
dc.subjectalpha-amylaseen_US
dc.subjectalpha-glucosidaseen_US
dc.subjectphenolicen_US
dc.subjectDPPHen_US
dc.subjectFRAPen_US
dc.titleGundelia Tournefortii L. (Kenger): Determination of in vitro Antidiabetic Activitiesen_US
dc.typeArticleen_US

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