Platinum (II) N-heterocyclic carbene complexes: Synthesis, characterization and cytotoxic properties

Basit Öğe Kaydı
dc.authoridkaraca, emine özge/0000-0003-2094-9742
dc.authoridÖzdemir, İsmail/0000-0001-6325-0216
dc.authoridAygün, Muhittin/0000-0001-9670-9062
dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authoridkaraca, emine ozge/0000-0002-3190-4438
dc.authoridOZDEMIR, ILKNUR/0000-0002-8566-8979
dc.authorwosidkaraca, emine özge/AAH-2535-2019
dc.authorwosidÖzdemir, İsmail/ABI-5192-2020
dc.authorwosidAygün, Muhittin/P-3605-2019
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.contributor.authorKaraca, Emine Ozge
dc.contributor.authorCiftci, Osman
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorYakali, Gul
dc.contributor.authorAygun, Muhittin
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:45:55Z
dc.date.available2024-08-04T20:45:55Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPlatinum (II) complexes bearing N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry, but there are very few reports of biological properties of this type of complexes. A series of [PtCl2(NHC)(PEt3)] complexes were synthesized. The structures of all compounds were characterized by H-1-NMR, C-13-NMR, IR and elemental analysis techniques, which supported the proposed structures. The single crystal structures of complexes 1a and 1e were determined. The title complexes show slightly distorted square-planar coordination around the platinum (II) metal center. The cytotoxic properties of the platinum (II)-NHC complexes have been assessed in various human cancer lines, including cisplatin-sensitive and resistant cells. IC50 values of these four complexes were determined by the MTS-based assay on three human cell lines-brain (SHSY5Y), colon (HTC116) and liver (HEP3B). These complexes have been highlighted cancer therapeutic agent with unique structures and functions.en_US
dc.description.sponsorshipTUBITAK [114Z624]en_US
dc.description.sponsorshipTUBITAK, Grant/Award Number: 114Z624en_US
dc.identifier.doi10.1002/aoc.4851
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85065401538en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/aoc.4851
dc.identifier.urihttps://hdl.handle.net/11616/98783
dc.identifier.volume33en_US
dc.identifier.wosWOS:000475943500035en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofApplied Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantitumor activityen_US
dc.subjectImidazolidine-2-ylideneen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectplatinum complexesen_US
dc.titlePlatinum (II) N-heterocyclic carbene complexes: Synthesis, characterization and cytotoxic propertiesen_US
dc.typeArticleen_US

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