Monitoring of cisplatin ototoxicity by distortion-product otoacoustic emissions

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dc.authorscopusid7003373872
dc.authorscopusid7102143488
dc.authorscopusid57206338912
dc.authorscopusid57197180977
dc.contributor.authorOzturan O.
dc.contributor.authorJerger J.
dc.contributor.authorLew H.
dc.contributor.authorLynch G.R.
dc.date.accessioned2024-08-04T19:59:29Z
dc.date.available2024-08-04T19:59:29Z
dc.date.issued1996
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCisplatin is one of the most commonly used chemotherapeutic agents. However, ototoxicity, in particular, damage to the outer hair cells of the cochlea, is one of its major side effects. Otoacoustic emissions are acoustical signals that originate from the contractile activity of the outer hair cells. They are transmitted from the cochlea to the external ear canal via the middle ear apparatus. Testing is quick, painless, objective, and non- invasive. Distortion-product otoacoustic emissions (DPOAEs) are one of the evoked types of otoacoustic emissions. They are quite sensitive to any insult to the outer hair cells, even before damage is manifested in pure tone audiometry (PTA). A patient, who was on cisplatin chemotherapy due to prostate cancer, was monitored periodically for ototoxicity using DPOAEs and PTA. DPOAEs were found to detect ototoxicity one course of chemotherapy earlier than PTA during cisplatin chemotherapy. The clinical application and sensitivity of DPOAEs in monitoring ototoxicity were discussed.en_US
dc.identifier.doi10.1016/S0385-8146(96)80023-X
dc.identifier.endpage151en_US
dc.identifier.issn0385-8146
dc.identifier.issue1en_US
dc.identifier.pmid8809338en_US
dc.identifier.scopus2-s2.0-0029934924en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage147en_US
dc.identifier.urihttps://doi.org/10.1016/S0385-8146(96)80023-X
dc.identifier.urihttps://hdl.handle.net/11616/90642
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofAuris Nasus Larynxen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcisplatinen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectcase reporten_US
dc.subjectevoked otoacoustic emissionen_US
dc.subjecthair cellen_US
dc.subjecthumanen_US
dc.subjectmaleen_US
dc.subjectototoxicityen_US
dc.subjectpatient monitoringen_US
dc.subjectprostate canceren_US
dc.subjectpure tone audiometryen_US
dc.titleMonitoring of cisplatin ototoxicity by distortion-product otoacoustic emissionsen_US
dc.typeArticleen_US

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