Effects of Calcium Channel Blockers on Trypsinogen Activation and Severity of Cerulein-induced Acute Pancreatitis in Rats

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dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridSatilmis, Basri/0000-0002-2538-5774
dc.authoridUyumlu, Ayşe Burçin/0000-0001-9517-9274
dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authorwosidSatilmis, Basri/JBR-9078-2023
dc.authorwosidSatilmis, Basri/C-5176-2019
dc.authorwosidUyumlu, Ayşe Burçin/ABH-5573-2020
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.contributor.authorUyumlu, A.
dc.contributor.authorSatilmis, B.
dc.contributor.authorBatcioglu, K.
dc.contributor.authorKaradag, N.
dc.contributor.authorGenc, M.
dc.date.accessioned2024-08-04T20:44:38Z
dc.date.available2024-08-04T20:44:38Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAcute pancreatitis is an inflammatory disease of the pancreas associated with high mortality but without a specific therapy. Intrapancreatic protease activation appears to be an early event in the development of acute pancreatitis but its association with pathogenesis has not been established. Recently it has been demonstrated that an enormous rise in the cytoplasmic Ca2+ levels of pancreatic acinar cells could be associated with the development of acute pancreatitis, thereby suggesting that Ca2+ channel could be a potential target for treatment. In this study, the protective effects of calcium channel blockers such as 2-aminoethoxydiphenyl borate, dantrolene and verapamil were investigated in cerulein-induced acute pancreatitis in vivo. Rats were divided into five groups. Group 1 (control), group 2 (cerulein, 100 mu g/kg), group 3 (cerulein+2-aminoethoxydiphenyl borate, mg/kg), group 4 (cerulein+dantrolene, 10 mg/kg) and group 5 (cerulein+verapamil, 2.5 mg/kg). Activities of amylase, lipase, cathepsin B, pancreatic secretory trypsin inhibitor, trypsin, levels of trypsinogen activation peptide and trypsinogen were measured addition to histological examination of the sections of pancreas. The results showed that cerulein increased the amylase, lipase and trypsin activities and trypsinogen activation peptide levels significantly. Administration of calcium channel blockers significantly protected the pancreas from histological damage (p<0.05). The results of this study demonstrated that calcium channel blockers can mitigate early protease activation and pancreas injury. It was suggested regulation of calcium channels would be relevant to maintain pancreatic acinar cell homeostasis and further research is necessary to understand the protective effects of calcium channel blockers.en_US
dc.description.sponsorshipIUBAPen_US
dc.description.sponsorshipIUBAP.en_US
dc.identifier.doi10.4172/pharmaceutical-sciences.1000383
dc.identifier.endpage502en_US
dc.identifier.issn0250-474X
dc.identifier.issn1998-3743
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85049672980en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage496en_US
dc.identifier.urihttps://doi.org/10.4172/pharmaceutical-sciences.1000383
dc.identifier.urihttps://hdl.handle.net/11616/98373
dc.identifier.volume80en_US
dc.identifier.wosWOS:000440512000012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute pancreatitisen_US
dc.subjectceruleinen_US
dc.subject2-aminoethoxydiphenyl borateen_US
dc.subjectdantroleneen_US
dc.subjectverapamilen_US
dc.titleEffects of Calcium Channel Blockers on Trypsinogen Activation and Severity of Cerulein-induced Acute Pancreatitis in Ratsen_US
dc.typeArticleen_US

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