Unexpectedly lower mortality rates in COVID-19 patients with and without type 2 diabetes in Istanbul

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dc.authoridDagdelen, Selcuk/0000-0002-0513-1750
dc.authoridTASCI, ILKER/0000-0002-0936-2476
dc.authoridSatman, Ilhan/0000-0001-8613-1797
dc.authoridDemirci, Ibrahim/0000-0003-0498-3115
dc.authoridSonmez, Alper/0000-0002-9309-7715
dc.authoridsahin, mustafa/0000-0002-4718-0083
dc.authoridcelik, osman/0000-0003-2131-2866
dc.authorwosidUstun, Yaprak/KFQ-9767-2024
dc.authorwosidDagdelen, Selcuk/A-9432-2017
dc.authorwosidUnluturk, Ugur/A-1988-2016
dc.authorwosidTASCI, ILKER/B-7556-2009
dc.authorwosidCelik, Osman/KLZ-6766-2024
dc.authorwosidArga, Kazım Yalçın/HGB-8786-2022
dc.authorwosidSatman, Ilhan/AAS-7044-2020
dc.contributor.authorSatman, Ilhan
dc.contributor.authorDemirci, Ibrahim
dc.contributor.authorHaymana, Cem
dc.contributor.authorTasci, Ilker
dc.contributor.authorSalman, Serpil
dc.contributor.authorAta, Naim
dc.contributor.authorDagdelen, Selcuk
dc.date.accessioned2024-08-04T20:49:26Z
dc.date.available2024-08-04T20:49:26Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAims: Type 2 diabetes mellitus (T2DM) is a risk factor for severe COVID-19. Our aim was to compare the clinical outcomes of patients with and without T2DM during the first hit of COVID-19 in Istanbul.& nbsp; Methods: A retrospective population-based study was conducted including all consecutive adult symptomatic COVID-19 cases. Patients were confirmed with rt-PCR; treated and monitored in accordance with standard protocols. The primary endpoints were hospitalization and 30-day mortality.& nbsp; Results: Of the 93,571 patients, 22.6% had T2DM, with older age and higher BMI. Propensity Score matched evaluation resulted in significantly higher rates of hospitalization (1.5-fold), 30-day mortality (1.6-fold), and pneumonia (1.4-fold). They revealed more severe laboratory deviations, comorbidities, and frequent drug usage than the Non-DM group. In T2DM age, pneumonia, hypertension, obesity, and insulin-based therapies were associated with an increased likelihood of hospitalization; whereas age, male gender, lymphopenia, obesity, and insulin treatment were considerably associated with higher odds of death.& nbsp; Conclusions: COVID-19 patients with T2DM had worse clinical outcomes with higher hospitalization and 30-day mortality rates than those without diabetes. Compared to most territories of the world, COVID-19 mortality was much lower in Istanbul, which may be associated with accessible healthcare provision and the younger structure of the population.& nbsp; (C)& nbsp;2021 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.diabres.2021.108753
dc.identifier.issn0168-8227
dc.identifier.issn1872-8227
dc.identifier.pmid33741352en_US
dc.identifier.scopus2-s2.0-85103232613en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.diabres.2021.108753
dc.identifier.urihttps://hdl.handle.net/11616/99854
dc.identifier.volume174en_US
dc.identifier.wosWOS:000647677900019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofDiabetes Research and Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectHospitalizationen_US
dc.subjectMortalityen_US
dc.subjectType 2 diabetes mellitusen_US
dc.subjectIstanbulen_US
dc.titleUnexpectedly lower mortality rates in COVID-19 patients with and without type 2 diabetes in Istanbulen_US
dc.typeArticleen_US

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