Histopathological and ultra-structural investigation of the damaging effects of hypoinsulinemia, hyper glycaemia and oxidative stress caused by parenteral nutrition combined with fasting on the small intestine of rabbits

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dc.authoridDemircan, Mehmet/0000-0002-4022-1276
dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridUremis, Muhammed Mehdi/0000-0003-2296-2422
dc.authorwosidDemircan, Mehmet/B-1904-2008
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidUremis, Muhammed Mehdi/HKP-0531-2023
dc.contributor.authorGurunluoglu, Semra
dc.contributor.authorGul, Mehmet
dc.contributor.authorGurunluoglu, Kubilay
dc.contributor.authorKocbiyik, Alper
dc.contributor.authorGul, Semir
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorUremis, Muhammed Mehdi
dc.date.accessioned2024-08-04T20:53:31Z
dc.date.available2024-08-04T20:53:31Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and study aims: Parenteral nutrition (PN) is a life-saving practice when the use of the gastrointestinal tract is not appropriate. Despite its great benefits, however, PN may cause several complications. In this study, we conducted histopathological and ultra-structural examinations of the effect of PN combined with starvation on the small intestines of rabbits.Materials and methods: Rabbits were divided into four groups. A fasting + PN group was left completely unfed and received all its daily required energy by PN through an intravenous central catheter. An oral feeding + PN group received half the necessary daily calories by oral feeding and the other half through PN. A semi-starvation group received only half the necessary daily calories by oral feeding and no PN. The fourth group, serving as a control, was supplied with its entire daily energy requirements through oral feeding. After 10 days, the rabbits were euthanized. Blood and small intestine tissue samples were collected from all groups. Blood samples were bio-chemically analysed, and tissue samples were examined by light and transmission electron microscopy.Results: The fasting + PN group exhibited lower insulin levels, higher glucose levels, and increased systemic oxidative stress than the other groups. Ultra-structural and histopathological examinations revealed a significant increase in apoptotic activity in this group's small intestines and a significant decrease in villus length and crypt depth. Severe damage to the intracellular organelles and nuclei of enterocytes was also observed.Conclusion: PN combined with starvation appears to cause apoptosis in the small intestine due to oxidative stress and hyperglycaemia with hypoinsulinemia, with destructive effects on small intestine tissue. Adding enteral nutrition to PN may reduce these destructive effects.en_US
dc.description.sponsorshipInonu University ' s Scientific Research Project Coordination Unit [TSA-2020-2284]en_US
dc.description.sponsorshipThis work was supported by Inonu University ' s Scientific Research Project Coordination Unit [project code TSA-2020-2284] .en_US
dc.identifier.doi10.1016/j.ajg.2023.02.003
dc.identifier.endpage135en_US
dc.identifier.issn1687-1979
dc.identifier.issn2090-2387
dc.identifier.issue2en_US
dc.identifier.pmid36890026en_US
dc.identifier.scopus2-s2.0-85150046697en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage129en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajg.2023.02.003
dc.identifier.urihttps://hdl.handle.net/11616/101225
dc.identifier.volume24en_US
dc.identifier.wosWOS:001020448300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofArab Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParenteral nutritionen_US
dc.subjectStarvationen_US
dc.subjectSmall intestineen_US
dc.subjectHistopathologyen_US
dc.subjectOxidative stressen_US
dc.titleHistopathological and ultra-structural investigation of the damaging effects of hypoinsulinemia, hyper glycaemia and oxidative stress caused by parenteral nutrition combined with fasting on the small intestine of rabbitsen_US
dc.typeArticleen_US

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