Dynamic contrast enhanced MRI in the differential diagnosis of soft tissue tumors

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dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.contributor.authorTuncbilek, N
dc.contributor.authorKarakas, HM
dc.contributor.authorOkten, OO
dc.date.accessioned2024-08-04T20:13:46Z
dc.date.available2024-08-04T20:13:46Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The value of the dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in differentiating benign and malignant soft tissue tumors was investigated. Materials and methods: Turbo FLASH DCE-MRI was performed on 22 subjects (2-74 years) with soft tissue tumors. Enhancement in the first min (E-max/1), second min (E-max/2) and maximum peak enhancement (E-max), and steepest slope were calculated. Discriminant analyses were performed to reveal parametric differences of benign and malignant lesions. Results: Diagnosis of benign (N = 10) tumors were hemangioma (n = 3), neurogenic tumor (n 3) lipoma (n = 2), giant cell tumor (n = 1) and desmoid (n = 1), whereas malignant lesions (N = 12) were classified as liposarcoma (n 5), malignant fibrous histiocytoma (n = 5) and synovial sarcoma (n = 2). For malignant lesions E-max/1 was 65-198%, E-max/2 was 65-145%, E-max was 78-198%, and steepest slope was 1.45-4.06. For benign lesions these values were 4-98%, 5-105%, 7-125% and 0.67-2.57, respectively. To determine the relation between the variables analysed, Pearson correlation coefficients were calculated. E-max was found to be highly correlated with other variables (rxy > 0.86, P < 0.0001). Consequently, this variable was excluded from the discriminant analysis. In order to determine discrimination of malignant and benign tumors using E-max/1, E-max/2, and steepest slope of the enhancement curve logistic regression was applied to the above mentioned data. When combined these parameters had a 95.5% of overall accuracy in classifying benign and malignant lesions (P = 0.004). Conclusion: DCE-MRI parameters that thought to be the surrogate markers of tumoral microcirculation and tissue perfusion provides a specific preoperative diagnosis. Dynamic imaging parameters are therefore advocated for monitoring the effect of chemotherapy in soft tissue tumors. (c) 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejrad.2004.04.012
dc.identifier.endpage505en_US
dc.identifier.issn0720-048X
dc.identifier.issue3en_US
dc.identifier.pmid15741025en_US
dc.identifier.scopus2-s2.0-14644390876en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage500en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejrad.2004.04.012
dc.identifier.urihttps://hdl.handle.net/11616/93826
dc.identifier.volume53en_US
dc.identifier.wosWOS:000227883300021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ireland Ltden_US
dc.relation.ispartofEuropean Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdynamic contrast enhanced MRIen_US
dc.subjectsemiquantitative enhancement parametersen_US
dc.subjectsoft tissue tumorsen_US
dc.subjectdifferential diagnosisen_US
dc.titleDynamic contrast enhanced MRI in the differential diagnosis of soft tissue tumorsen_US
dc.typeArticleen_US

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