Hemodiyaliz hastalarında intradiyalitik parenteral esansiyel amino asit tedavisinin etkileri
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Dosyalar
Tarih
1995
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi Tıp Fakültesi Dergisi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Vücut kitle indeksleri düşük olan kronik hemodiyaliz (HD) programındaki 19 (11 K, 8 E) üremik hastaya 3 ay süre ile her diyaliz seansının son 2 saatinde 250 ml % 5.4'lük Esansiyel Amino Asit (EAA) solüsyonu ile birlikte 500 ml % 10'luk dekstroz infüzyonu uygulayarak, bu tedavinin; vücut ağırlığı, vücut kitle indeksi (BM1), serum albumin ve transferrin düzeyi, PPD, total lenfosit sayısı ve protein katabolizma hızı (PCR) gibi nutrisyonel parametreler üzerine etkisini araştırdık.
Hastaların yaş ortalaması 48±6 (36-60) yıl ve vücut ağırlığı 52±3.5 kg idi. Ortalama 12±4 aydan beri HD'e giriyorlardı. Hastaların tedavi öncesi 1 g 'kg/gün protein ve 35 kcal/kg/gün kalori ihtiva eden diyetleri tedavi süresince değiştirilmeden aynen uygulandı.
Sonuç olarak; BMVleri düşük olan kronik HD hastalarında intradiyalitik parenteral EAA infuzyonunun azotemiyi etkilemeksizin BM1, serum albumin ve transferrin düzeyi ile PCR’ı önemli derecede artırarak bozulmuş olan nutrisyonel durumu iyileştirdiği tespit edilmiştir.
We administered intradialytic parenteral assential amino acid (EAA) solution to 19 uremic patients with low body mass index (8M, 11 F; mean age : 48±6 years) for 3 months, undergoing hemodialysis (HD) three times per week and investigated the effects of this treatment on some nutritional parameters such as body weight (bw), body mass index (BM1), serum albumin and transferrin levels, protein catabolic rate (PCR), tuberculin skin test (PPD) and total lymphocyte counts. Mean bw of the patients was 52±3.5 kg and HD duration was 12±4 months. Patients received same diet before and during this supplementation period (protein : lg/kg/day, energy : 35 kcal/kg/day). Two hundred and fifty ml of EAA solution (NephrAmine)R including 12.7 g EAA was administered to each patient during the last 2 hours of each dialysis session three times per week. All patients simultaneously received 500 ml of 10% glucose. In conclusion, we found that intradialytic parenteral EAA administration significantly increased serum albumin and transferrin levels, BM1 and PCR values without changing blood urae nitrogen levels and partially improved nutritional status.
We administered intradialytic parenteral assential amino acid (EAA) solution to 19 uremic patients with low body mass index (8M, 11 F; mean age : 48±6 years) for 3 months, undergoing hemodialysis (HD) three times per week and investigated the effects of this treatment on some nutritional parameters such as body weight (bw), body mass index (BM1), serum albumin and transferrin levels, protein catabolic rate (PCR), tuberculin skin test (PPD) and total lymphocyte counts. Mean bw of the patients was 52±3.5 kg and HD duration was 12±4 months. Patients received same diet before and during this supplementation period (protein : lg/kg/day, energy : 35 kcal/kg/day). Two hundred and fifty ml of EAA solution (NephrAmine)R including 12.7 g EAA was administered to each patient during the last 2 hours of each dialysis session three times per week. All patients simultaneously received 500 ml of 10% glucose. In conclusion, we found that intradialytic parenteral EAA administration significantly increased serum albumin and transferrin levels, BM1 and PCR values without changing blood urae nitrogen levels and partially improved nutritional status.
Açıklama
[Journal of Turgut Özal Medical Center 2(2): 155-159,1995]
Anahtar Kelimeler
Hemodiyaliz, Esansiyel amino asit tedavis, Kronik Böbrek Yetmezliği, Malnutrisyon, Protein katabolizma hızı, Hemodialysis, Essential amino acid supplementation, Chronic renal failure, Malnutrition, Protein catabolic rate
Kaynak
Turgut Özal Tıp Merkezi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
2
Sayı
2
Künye
Tonbul, H.Zeki., San, A., Selçuk, N.Yılmaz., Akarsu, E.,Soypaçıcı, Z.,Akçay, F.,(1995). Hemodiyaliz hastalarında intradiyalitik parenteral esansiyel amino asit tedavisinin etkileri.Turgut Özal Tıp Merkezi Dergisi, 2 (2).155-159 ss.
