Antioxidant and antithrombotic properties of fruit, leaf, and seed extracts of the Halhal? olive (Olea europaea L.) native to the Hatay region in Turkey

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dc.authoridalagoz, mehmet abdullah/0000-0001-5190-7196
dc.authoridKucukbay, Fatumetuzzehra/0000-0001-7784-4138
dc.authorwosidGÜNAL, SELAMİ/HSG-2288-2023
dc.authorwosidalagoz, mehmet abdullah/W-7847-2018
dc.contributor.authorBatcioglu, Kadir
dc.contributor.authorKucukbay, Fatumetuzzehra
dc.contributor.authorAlagoz, Mehmet Abdullah
dc.contributor.authorGunal, Selami
dc.contributor.authorYilmaztekin, Yakup
dc.date.accessioned2024-08-04T20:53:32Z
dc.date.available2024-08-04T20:53:32Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe olive (Olea europaea L.) is one of the most important plants grown in many Mediterranean countries that has a high economic value. Olives, which are specific to each region, have different bioactive components. In this study, we investigated the phenolic/flavonoid contents, as well as antioxidant, antimicrobial, and antithrombotic activities of the fruit, leaf, and seed extracts obtained from the Halhali olive grown in Arsuz district of Hatay, Turkey. Antioxidant activities of the phenolic compounds found in the olive fruit, seed, and leaf extracts were determined by employing established in vitro systems. Total phenolics were determined as gallic acid equivalents, while total flavonoids were determined as quercetin equivalents. Also, we evaluated a possible interaction between oleuropein and aggregation-related glycoproteins of the platelet surface via docking studies. The extracts showed effective antioxidant activity. The seed extract had the highest phenolic content of 317.24 mu g GAE, while the fruit extract had the highest flavonoid content of 4.43 mu g. The highest potential for metal chelating activity was found in the leaf extract, with an IC50 value of 13.33 mg/mL. Also, the leaf extract showed higher levels of antioxidant, antithrombotic, and antimicrobial activity, compared to the fruit and seed extracts. The docking scores of oleuropein against the target molecules GPVI, alpha 2 beta 1, and GPIb alpha were calculated as -3.798, -4.315, and -6.464 kcal/mol, respectively. The olive fruit, leaf, and seed extracts used as experimental material in our study have remarkable antioxidant, antimicrobial, and antithrombotic potential.en_US
dc.description.sponsorshipInoenue University (INUE), Turkey [TYL-2016-143]en_US
dc.description.sponsorshipThe authors thank Inoenue University (INUE), Turkey (BAPB - Grant No. TYL-2016-143) for financial support.en_US
dc.identifier.doi10.21603/2308-4057-2023-1-557
dc.identifier.endpage93en_US
dc.identifier.issn2308-4057
dc.identifier.issn2310-9599
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85150424990en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage84en_US
dc.identifier.urihttps://doi.org/10.21603/2308-4057-2023-1-557
dc.identifier.urihttps://hdl.handle.net/11616/101232
dc.identifier.volume11en_US
dc.identifier.wosWOS:000972522500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKemerovo State Univen_US
dc.relation.ispartofFoods and Raw Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOlea europaea Len_US
dc.subjectantioxidanten_US
dc.subjectantithrombotic activityen_US
dc.subjectantimicrobial activityen_US
dc.subjectmolecular dockingen_US
dc.titleAntioxidant and antithrombotic properties of fruit, leaf, and seed extracts of the Halhal? olive (Olea europaea L.) native to the Hatay region in Turkeyen_US
dc.typeArticleen_US

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