Carbontetrachloride induced acute liver damage and protective effect of n-acetylcysteine on rats with regenerated and non-regenerated liver

Basit Öğe Kaydı
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridBilgic, Sedat/0000-0001-8410-2685
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidBİLGİÇ, Sedat/AEM-2044-2022
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.authorwosidbilgiç, sedat/JVN-5459-2024
dc.contributor.authorBilgic, Sedat
dc.contributor.authorOzerol, Elif
dc.contributor.authorIraz, Mustafa
dc.contributor.authorSahin, Nurhan
dc.contributor.authorTanbek, Kevser
dc.contributor.authorCigli, Ahmet
dc.date.accessioned2024-08-04T20:41:47Z
dc.date.available2024-08-04T20:41:47Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Our aim was to investigate 70% partial hepatectomy (PH) groups, compare with not subjected to PH groups after exposure to hepatotoxic agents for alterations in the protective effects of antioxidant agents and sensitivity of the liver. Accordingly, we aimed to investigate the toxicity of a hepatotoxic agent, carbon tetrachloride (CCl4), and protective effects of an antioxidant, N-acetylcysteine (NAC), in experimental animal model. Methods: 67 male Wistar Albino rats were divided into 2 main groups to total 9 subgroups: group 1, underwent PH; group 2, not subjected to PH. 0.5 ml/kg CCl4 and 50 mg/kg NAC was given intraperitoneally (i.p.) to the groups. On postoperative day 9, 70% PH was performed according to the method of Higgins and Anderson. Finally, all rats were humanely killed. Results: Catalase (CAT) and superoxide dismutase (SOD) activities were significantly lower in both groups when CCl4 was administered. NAC treatment was found to significantly increase these parameters (P<0.05). Malondialdehyde (MDA) and protein carbonyl (PC) levels were significantly greater in both groups when CCl4 was administered (P<0.05). NAC treatment was found to significantly reduce these parameters. Conclusion: These results indicated that CCl4 increased oxidation products, reduced liver enzymatic activity and reduced proliferation activity in both hepatectomised and nonhepatectomised liver. The liver injury of CCl4 and the protective effect of NAC was similarly in both main groups. Consequently, making PH may not create a negative effect and an additional health problems in liver. Thus, these results can positively affect the decisions of the healthy liver donors.en_US
dc.identifier.doi10.1515/tjb-2016-0029
dc.identifier.endpage197en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84971631997en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage189en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2016-0029
dc.identifier.urihttps://hdl.handle.net/11616/97352
dc.identifier.volume41en_US
dc.identifier.wosWOS:000377541000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPartial hepatectomyen_US
dc.subjectliveren_US
dc.subjectNAC (N-acetylcysteine)en_US
dc.subjectCCl4 (carbon tetrachloride)en_US
dc.titleCarbontetrachloride induced acute liver damage and protective effect of n-acetylcysteine on rats with regenerated and non-regenerated liveren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu