Adrenomedullin and total nitrite levels in children with Henoch-Schonlein purpura

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dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridBalat, Ayse/0000-0002-8904-1348;
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidBalat, Ayse/JOZ-8426-2023
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.contributor.authorIslek, I
dc.contributor.authorBalat, A
dc.contributor.authorÇekmen, M
dc.contributor.authorYürekli, M
dc.contributor.authorMuslu, A
dc.contributor.authorSahinöz, S
dc.contributor.authorSivasli, E
dc.date.accessioned2024-08-04T20:13:29Z
dc.date.available2024-08-04T20:13:29Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNitric oxide (NO) is synthesized from endothelium and has an important role in the control of vascular tonus. Adrenomedullin (AM) is a potent vasodilator, and cytoprotective peptide is produced not only in adrenal medulla, but also in the vascular smooth muscle and endothelial cells. To investigate the endothelial synthesis of AM and NO, and endothelial injury in Henoch-Schonlein purpura (HSP), we measured their levels in 16 children with HSP, who were evaluated during the acute and remission phases, and compared with 12 healthy controls. Plasma AM levels (pmol/ml) were significantly higher in acute phase children (46.87+/-11.49) than in those in remission (35.59+/-12.39, p<0.01) and controls (30.70+/-9.12, p<0.001). Similarly, plasma total nitrite levels (mumol/l) were higher in acute phase patients (47.50+/-12.30) than in those in remission (35.94+/-10.08, p<0.005) and controls (34.56+/-11.51, p<0.05). Urinary excretion of AM (pmol/mg creatinine) was higher in acute phase patients (53.85+/-23.22) than in remission patients (29.97+/-9.33, p<0.01) and controls (37.43+/-15.78, p<0.05). Patients had increased urinary nitrite excretion (mumol/mg creatinine) in acute phase (2.39+/-1.18) compared to those in remission (1.53+/-0.90, p<0.05) and controls (1.05+/-0.61, p<0.005). There was no significant difference between remission phase and controls in AM and nitrite levels (p>0.05). This study concluded that AM and NO may have a role in the immunoinflammatory process of HSP, especially in the active stage, although whether this perpetuates, or protects against, further vascular injury is not clear. Further studies are needed to clearly establish the roles of AM and NO in the pathogenesis of HSP.en_US
dc.identifier.doi10.1007/s00467-003-1193-2
dc.identifier.endpage1137en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue11en_US
dc.identifier.pmid12920627en_US
dc.identifier.scopus2-s2.0-0242610291en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1132en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-003-1193-2
dc.identifier.urihttps://hdl.handle.net/11616/93658
dc.identifier.volume18en_US
dc.identifier.wosWOS:000186244100009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectHenoch-Schonlein purpuraen_US
dc.subjectnitric oxideen_US
dc.titleAdrenomedullin and total nitrite levels in children with Henoch-Schonlein purpuraen_US
dc.typeArticleen_US

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