Synthesis and characterization of some new 2(3H)-benzoxazolones with analgesic and antiinflammatory activities

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dc.authoridÜnüvar, Songül/0000-0001-8454-490X
dc.authoridKoksal, Meric/0000-0001-7662-9364
dc.authoridAKTAY, Goknur/0000-0002-1646-8674
dc.authorwosidGokhan-Kelekci, Nesrin/D-6502-2018
dc.authorwosidÜnüvar, Songül/ABH-5516-2020
dc.contributor.authorGoekhan-Kelekci, Nesrin
dc.contributor.authorKoeksal, Meric
dc.contributor.authorUenuevar, Songuel
dc.contributor.authorAktay, Goeknur
dc.contributor.authorErdogan, Hakki
dc.date.accessioned2024-08-04T20:31:07Z
dc.date.available2024-08-04T20:31:07Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe synthesis, characterization and pharmacological activities of a new series of (6-difluorobenzoyl)-5-methyl-3-benzoylmethyl-2(3H)-benzoxazolone and 5-methyl-3-(2-hydroxyl-2-phenylethyl)-2(3H)-benzoxazolone are described. Antiinflammatory activity was investigated by the carrageenin-induced paw oedema test and analgesic activity by acetic acid writhing and hot plate tests in mice. Among the synthesized compounds, compound 3e 6-(2,5-difluorobenzoyl)-3-(4-bromobenzoylmethyl-2(3H)-benzoxazolone was found to be the most promising compound for analgesic activity. Reduced compounds (4a-4d) displayed considerable anti-inflammatory activity compared to the other derivatives.en_US
dc.description.sponsorshipHacettepe University Research Center Fund [05 D 301002]en_US
dc.description.sponsorshipThis study was supported by the Hacettepe University Research Center Fund (Project number: 05 D 301002).en_US
dc.identifier.doi10.1080/14756360701841772
dc.identifier.endpage37en_US
dc.identifier.issn1475-6366
dc.identifier.issue1en_US
dc.identifier.pmid19127481en_US
dc.identifier.scopus2-s2.0-58949085635en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1080/14756360701841772
dc.identifier.urihttps://hdl.handle.net/11616/94741
dc.identifier.volume24en_US
dc.identifier.wosWOS:000262718700005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2(3H)-Benzoxazoloneen_US
dc.subjectanalgesic-antiinflammatory activitiesen_US
dc.titleSynthesis and characterization of some new 2(3H)-benzoxazolones with analgesic and antiinflammatory activitiesen_US
dc.typeArticleen_US

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