The effects of acute normovolemic hemodilution on coagulation parameters in coronary artery bypass surgery

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dc.authorscopusid34569135700
dc.authorscopusid15073106000
dc.authorscopusid8932188900
dc.authorscopusid10739108800
dc.authorscopusid6603951627
dc.authorscopusid7004486274
dc.contributor.authorDurmuş M.
dc.contributor.authorKaraaslan K.
dc.contributor.authorBut A.K.
dc.contributor.authorErdem T.B.
dc.contributor.authorSezgin N.
dc.contributor.authorErsoy M.Ö.
dc.date.accessioned2024-08-04T20:00:57Z
dc.date.available2024-08-04T20:00:57Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAcute normovolemic hemodilution reduces allogenic blood transfusion requirements during surgery. We aimed to investigate the effects of acute normovolemic hemodilution on hemostasis after cardiopulmonary bypass by comparing routine coagulation tests, thrombin-antithrombin III complex, fibrinogen, D-dimer, protein C and S levels. After Ethics Committee approval 40 patients undergoing coronary artery bypass surgery were divided into two groups randomly. After induction of anesthesia, one or two units of blood were drawn from the Group I (n=20) until the hematocrit values became less than < 35% (Htc < 35%). At the same time, volume replacement was achieved with same amount of colloid infusion from peripheral veins. No additional procedure was done to Group II (n=20). All coagulation tests were measured before induction, at the end of surgery, at postoperative 6th and 24th. In addition to this time periods, thrombin-antithrombin III complex, fibrinogen and D-dimer levels were measured before cardiopulmonary bypass. The amount of transfused allogenic blood was lower in Group I compared to Group II (p<0.05). Routine coagulation tests remained within normal limits. Before cardiopulmonary bypass, fibrinogen, thrombin-antithrombin III complex and D-dimer levels were higher in Group I compared to Group II statistically (p<0.05). Protein C level was less at the end of surgery in Group I (p<0.05). Fragmentation ratio was detected lower in Group I than Group II (P<0.01). We concluded that, although acute normovolemic hemodilution reduces allogenic blood transfusion requirement and fragmentation ratio, it may activate coagulation and fibrinolysis in patients undergoing coronary artery bypass surgery.en_US
dc.identifier.endpage206en_US
dc.identifier.issn1300-0578
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-0141953856en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://hdl.handle.net/11616/91138
dc.identifier.volume11en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofAnestezi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoagulationen_US
dc.subjectCoronary artery bypass surgeryen_US
dc.subjectFibrinolysisen_US
dc.subjectHemodilutionen_US
dc.titleThe effects of acute normovolemic hemodilution on coagulation parameters in coronary artery bypass surgeryen_US
dc.title.alternativeKoroner by-pass cerrahisinde akut normovolemik hemodilüsyonun koagülasyon parametrelerine etkisien_US
dc.typeArticleen_US

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