Synthesis of Cyclodextrin-Based Multifunctional Biocompatible Hydrogels and Their Use in the Prevention of Intrauterine Adhesions (Asherman’s Syndrome) after Surgical Injury

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dc.authorscopusid58992819500
dc.authorscopusid7801545386
dc.authorscopusid24776974100
dc.authorscopusid55193447200
dc.authorscopusid55987303600
dc.authorscopusid55752795000
dc.authorscopusid6507504123
dc.contributor.authorAksoy Erden B.
dc.contributor.authorKurus M.
dc.contributor.authorTurkcuoglu I.
dc.contributor.authorMelekoglu R.
dc.contributor.authorBalcioglu S.
dc.contributor.authorYigitcan B.
dc.contributor.authorAtes B.
dc.date.accessioned2024-08-04T20:03:42Z
dc.date.available2024-08-04T20:03:42Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAsherman’s syndrome, which can occur during the regeneration of damaged uterine tissue after surgical interventions, is a significant health problem in women. This study aimed to acquire and characterize cyclodextrin-based hydrogels, which can be used to prevent Asherman’s syndrome, and investigate their effectiveness with biomedical applications. A series of hydrogels were synthesized from the cross-linking of ?-cyclodextrin and different polyphenols with epoxy-functional PEG. Their chemical, physical, and biological properties were subsequently determined. The results demonstrated that the cyclodextrin-based hydrogels had a porous structure, high swelling ratio, good injectability, drug release ability, and antioxidant activity. Cell culture results illustrated that the hydrogels had no significant cytotoxicity toward L929 fibroblast cells. Considering all properties, the ?-CD-PEG-600-Ec hydrogel showed the most satisfactory properties rather than other ones. The potential of this hydrogel in preventing Asherman’s syndrome was evaluated in a rat model. The results revealed that the ?-estradiol- and melatonin-loaded cyclodextrin-based multifunctional hydrogel group both structurally and mechanically showed an antiadhesion effect in the uterus and a therapeutic effect on the damage with the ?-estradiol and melatonin that it contains compared to the Asherman (ASH) group. This double drug-loaded hydrogel can be a promising candidate for preventing Asherman’s syndrome due to its versatile properties. © 2024 The Authors. Published by American Chemical Society.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 215Z322; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAKen_US
dc.description.sponsorshipThis work was supported financially by the Scientific and Technological Research Council of Turkey (TU\u0308BI\u0307TAK) [Project no. 215Z322].en_US
dc.identifier.doi10.1021/acsomega.4c03655
dc.identifier.endpage31973en_US
dc.identifier.issn2470-1343
dc.identifier.issue29en_US
dc.identifier.scopus2-s2.0-85198539317en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage31957en_US
dc.identifier.urihttps://doi.org/10.1021/acsomega.4c03655
dc.identifier.urihttps://hdl.handle.net/11616/92029
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofACS Omegaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleSynthesis of Cyclodextrin-Based Multifunctional Biocompatible Hydrogels and Their Use in the Prevention of Intrauterine Adhesions (Asherman’s Syndrome) after Surgical Injuryen_US
dc.typeArticleen_US

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