Alamandine: Protective Effects Against Renal Ischemia-Reperfusion Injury-Induced Renal and Liver Damage in Diabetic Rats

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dc.contributor.authorCengiz, Ayse Nuransoy
dc.contributor.authorOzhan, Onural
dc.contributor.authorTanriverdi, Lokman Hekim
dc.contributor.authorDogru, Feyzi
dc.contributor.authorYildiz, Azibe
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardi, Nigar
dc.date.accessioned2026-04-04T13:37:38Z
dc.date.available2026-04-04T13:37:38Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractAlamandine (ALA) is a heptapeptide discovered in 2013 within the renin-angiotensin system (RAS). Given the high prevalence of diabetes mellitus (DM) in society and its comorbidities, especially renal failure, which significantly impairs the quality of life, this study aimed to investigate the protective effects of ALA against renal ischemia-reperfusion (I/R) injury in diabetic rats. Our aim was to develop preventive therapies for DM and diabetic renal failure. Forty-eight 3-month-old male Sprague-Dawley rats were induced by administering a single intraperitoneal dose of 50 mg/kg of streptozotocin (STZ). Rats were divided into four groups. Right nephrectomy was performed through dorsolateral incisions in all rats, followed by occlusion of the left renal vessels for 1 h to induce ischemia. Reperfusion of the left kidney was initiated by removing the clamp and allowing 24 h of reperfusion. Histopathological examination of the kidney tissues revealed necrotic changes and tubular dilatation in the I/R group, which were significantly reduced in the ALA + I/R group. Immunohistochemical analysis showed increased immunoreactivity for interleukin-6 (IL-6) and caspase-3 in the I/R group, whereas the ALA + I/R group demonstrated significantly lower immunoreactivity for these markers. Liver histology showed irregular hepatocyte cords and sinusoidal dilatation in the I/R group, whereas the ALA + I/R group exhibited a preserved classical lobular structure with reduced histopathological changes. Blood parameters, serum biochemistry, and tissue findings were also analyzed. Our study demonstrated the protective effects of ALA on renal and liver tissues against damage induced by renal I/R injury in a diabetic background. Moreover, ALA exhibited protective effects against liver damage resulting from renal I/R injury.
dc.description.sponsorshipInonu University Scientific Research Projects Unit [TSA-2022-2781]
dc.description.sponsorshipThis study was financially supported by the Inonu University Scientific Research Projects Unit (project number: TSA-2022-2781).
dc.identifier.doi10.1002/jbt.70423
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue8
dc.identifier.orcid0000-0003-4263-5234
dc.identifier.orcid0000-0001-9018-7849
dc.identifier.orcid0000-0002-6920-3856
dc.identifier.orcid0000-0001-9497-3468
dc.identifier.orcid0000-0002-7949-9582
dc.identifier.pmid40741878
dc.identifier.scopus2-s2.0-105012360565
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.70423
dc.identifier.urihttps://hdl.handle.net/11616/109961
dc.identifier.volume39
dc.identifier.wosWOS:001542360700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectdiabetic complications
dc.subjectliver damage
dc.subjectremote organ injury
dc.subjectrenal failure
dc.subjectrenin-angiotensin system
dc.titleAlamandine: Protective Effects Against Renal Ischemia-Reperfusion Injury-Induced Renal and Liver Damage in Diabetic Rats
dc.typeArticle

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