Efficacy of hyperbaric oxygen therapy on central corneal thickness, intraocular pressure, and nerve fiber layer in patients with type 2 diabetes: A prospective cohort study

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dc.authorscopusid55755921600
dc.authorscopusid56979203900
dc.authorscopusid57208741817
dc.authorscopusid35301469100
dc.contributor.authorKaldirim H.
dc.contributor.authorAtalay K.
dc.contributor.authorCeylan B.
dc.contributor.authorYazgan S.
dc.date.accessioned2024-08-04T19:59:39Z
dc.date.available2024-08-04T19:59:39Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To evaluate the effect of hyperbaric oxygen therapy (HBOT) on central corneal thickness (CCT), intraocular pressure (IOP), and the retinal nerve fiber layer (RNFL) thickness in patients with type 2 diabetes mellitus. Methods: This prospective non-randomized cohort study consisted of type 2 diabetes mellitus patients who received 30 sessions of HBOT for diabetic foot ulcer. The CCT, IOP, and RNFL measured at baseline, after the 10th session of HBOT, after the 20th session of HBOT, after the 30th session of HBOT, and after the 3 months of the last session of HBOT. We gained the superior-nasal, superior-temporal, inferior-nasal, inferior-temporal, nasal and temporal quadrant RNFL values with a spectral-domain optical coharence tomography. Results: Forty-six eyes of 46 patients included in the study. During the study period, a statistically significant increase in mean IOP values compared to baseline was observed (p < 0.001). We found no significant changes at CCT and all quadrants of RNFL values during HBOT and after 3 months of the treatment (p > 0.05). During the study period, the IOP levels increased over 21 mmHg (between 22 and 28 mmHg) in seven eyes (15.2%). The mean hemoglobin A1c values of these patients with IOP >21 mmHg were 8.2 ± 0.9 mg/dL, and there was significant differences compared with those of patients with IOP values ?21 mmHg (7.4 ± 2.8 mg/dL) (p = 0.001). Conclusions: HBOT increase IOP in type 2 diabetic patients especially in ones with impaired blood glucose regulation. However, it does not cause any changes in CCT and RNFL. As diabetic retinopathy and diabetic foot ulcer are in common pathologies, thus this brief report concludes a need for further studies with longer follow-up periods to explore the potential interaction of HBOT on CCT, IOP, and RNFL. © 2021 The Korean Ophthalmological Society.en_US
dc.identifier.doi10.3341/KJO.2020.0076
dc.identifier.endpage9en_US
dc.identifier.issn1011-8942
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85102509505en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.3341/KJO.2020.0076
dc.identifier.urihttps://hdl.handle.net/11616/90800
dc.identifier.volume35en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKorean Ophthalmological Society (KOS)en_US
dc.relation.ispartofKorean Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCentral corneal thicknessen_US
dc.subjectHyperbaric oxygenationen_US
dc.subjectIntraocular pressureen_US
dc.subjectRetinal nerve fiber layeren_US
dc.subjectType 2 diabetes mellitusen_US
dc.titleEfficacy of hyperbaric oxygen therapy on central corneal thickness, intraocular pressure, and nerve fiber layer in patients with type 2 diabetes: A prospective cohort studyen_US
dc.typeArticleen_US

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