The Effects of Hypothyroidism Due to Iodine Deficiency in Neonatal Brain: The Changes in Brain Metabolites Detected by Magnetic Resonance Spectroscopy

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dc.authorscopusid7003868986
dc.authorscopusid6603854521
dc.contributor.authorAkinci A.
dc.contributor.authorKarakaŞ H.M.
dc.date.accessioned2024-08-04T20:03:54Z
dc.date.available2024-08-04T20:03:54Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMost studies show that iodine deficiency and maternal-fetal hypothyroxinemia have negative effects on fetal neural maturation, dendritic arborization and synaptic formation. They delay the myelinization process and gliogenesis, which start in the second half of gestation and continue in postnatal life. Altered levels of iodine are correlated with defective brain development and neuronal maturation. Various degrees of irreversible neurocognitive defects that are caused by severe iodine deficiency, and subsequent maternal and fetal hypothyroxinemia are wellknown. Recent studies further showed that, even in cases without clinical hypothyroidism, maternal hypothyroxinemia due to mild-to-moderate iodine deficiency would lead to fetal brain damage that could be reversed with early thyroxine therapy. Magnetic resonance spectroscopy (MRS) is a sensitive technique that detects alterations in brain metabolite levels in various neurodevelopmental disorders. The most prominent MRS change in congenital hypothyrodism due to iodine deficiency is decreased NAA level. Decreased NAA level that is caused by maternal and fetal hypothyroxinemia due to iodine deficiency implies the adverse effect of intrauterine hypothyroxinemia on fetal neuronal development. Iodine deficiency at any degree of severity causes maternal and fetal hypothyroxinemia. As thyroid hormones of the mother and the fetus must be kept at optimal levels, iodine prophylaxis should be provided, especially in iodine deficient areas. To establish normal fetal brain development, iodine supplementation must be started before pregnancy and should be continued during the gestational period. © 2009 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-12-374135-6.00065-0
dc.identifier.endpage634en_US
dc.identifier.isbn9780123741356
dc.identifier.scopus2-s2.0-85137234776en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage625en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-12-374135-6.00065-0
dc.identifier.urihttps://hdl.handle.net/11616/92186
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofComprehensive Handbook of Iodine: Nutritional, Biochemical, Pathological and Therapeutic Aspectsen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe Effects of Hypothyroidism Due to Iodine Deficiency in Neonatal Brain: The Changes in Brain Metabolites Detected by Magnetic Resonance Spectroscopyen_US
dc.typeBook Chapteren_US

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