Effects of polyunsaturated fatty acids on lipid metabolism and their mechanisms: Which fat?

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dc.authorscopusid6602634150
dc.contributor.authorGüld?ur T.
dc.date.accessioned2024-08-04T19:59:39Z
dc.date.available2024-08-04T19:59:39Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn addition to their roles as membran components and fuel molecules, polyunsaturated fatty acids (PUFAs) have gained much attention for their role in regulating gene expression. PUFAs modify gene expressions of lipid-lipoprotein metabolism by binding to specific nuclear receptors and transcription factors e.g. peroxisome proliferator activated receptors (PPAR). Dietary n-3 PUFA supplementation in humans is associated with significantly lower level of VLDL triacylglycerol and apo B synthesis. However effects of n-3 PUFAs on LDL and HDL cholesterol appear to be inconsistent. On the other hand, humans consuming diet rich in n-6 PUFAs have lower total and LDL-cholesterol. Changes in n-6:n-3 PUFA ratios have the potential to significantly influence the production of inflammatory eicosanoids and to contribute to the inflammation mediated chronic diseases such as atherosclerosis. PUFAs have been the subjects of nutrigenomic studies. Genetic differences among individuals have been indicated to be responsible for variations in response to dietary PUFAs.For example, a PPAR ? single nucleotidpolymorphism modulates the association between plasma lipid concentration and dietary n-6 and n-3 fatty acid intake. With the identification and understanding of individual differences in gen expression in response to diet, we will then, perhaps, be able to answer the following questions: Which fat? To whom?en_US
dc.identifier.doi10.1501/eczfak_0000000527
dc.identifier.endpage210en_US
dc.identifier.issn1015-3918
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84875997520en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage191en_US
dc.identifier.urihttps://doi.org/10.1501/eczfak_0000000527
dc.identifier.urihttps://hdl.handle.net/11616/90803
dc.identifier.volume38en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectLipid metabolismen_US
dc.subjectNuclear receptorsen_US
dc.subjectNutrigenomicsen_US
dc.subjectPolyunsaturated fatty acidsen_US
dc.titleEffects of polyunsaturated fatty acids on lipid metabolism and their mechanisms: Which fat?en_US
dc.title.alternativeÇoklu doymamiş ya? asi?tleri?ni?n li?pi?d metaboli?zmasina etki?leri? ve etki? mekani?zmalari: Hangi? ya??en_US
dc.typeReview Articleen_US

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