The effects of N-acetylcysteine on pulmonary functions in patients undergoing on-pump coronary artery surgery: a double blind placebo controlled study

Basit Öğe Kaydı
dc.authoridErdil, Feray Akgül/0000-0002-7544-3717
dc.authoridAKÇA, BARIŞ/0000-0001-9154-4764
dc.authoriddisli, olcay murat/0000-0002-9699-4817
dc.authoridErdil, Nevzat/0000-0002-8275-840X
dc.authorwosidColak, M. Cengiz/ABI-3394-2020
dc.authorwosidBattaloglu, Bektas/ABI-6211-2020
dc.authorwosidErdil, Feray Akgül/ABI-2474-2020
dc.authorwosidAKÇA, BARIŞ/ABG-7339-2020
dc.authorwosiddisli, olcay murat/ABI-3289-2020
dc.authorwosidErdil, Nevzat/K-8079-2019
dc.contributor.authorErdil, N.
dc.contributor.authorEroglu, T.
dc.contributor.authorAkca, B.
dc.contributor.authorDisli, O. M.
dc.contributor.authorYetkin, O.
dc.contributor.authorColak, M. C.
dc.contributor.authorErdil, F.
dc.date.accessioned2024-08-04T20:41:30Z
dc.date.available2024-08-04T20:41:30Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the effects of N-acetylcysteine (NAC) on pulmonary function tests and arterial blood gases in patients undergoing on-pump coronary artery surgery. PATIENTS AND METHODS: The effect of NAC was assessed within the scope of a prospective, single center, double-blind, placebo-controlled, parallel group study. Eighty-two patients undergoing coronary artery bypass grafting were randomized into two groups to receive either placebo (group 1, n = 40) or NAC (group 2, n=42). Both the NAC group and the placebo-receiving control group also included a COPD subgroup consisting of patients with an FEV1/FVC ratio of < 0.7 and an FEV1 value of 50-80%. Pulmonary function tests were performed preoperatively and on postoperative day 60. RESULTS: Both groups were similar with respect to age, gender, preoperative risk factors, ejection fraction (EF), mean cross-clamp time, ventilation time, intensive care unit (ICU) stay, atrial fibrillation (AF) and hospital stay (p > 0.05). Postoperative FVC and FEV1 values in group 1 and the postoperative FEV1, FEV1/FVC and FEF 25-75 values in group 2 were lower in comparison to their preoperative values. However, in both group 1 and 2, the decreases observed in these parameters were not statistically significant (p > 0.05). In the COPD subgroup of group 1, a postoperative decrease was observed in the FEV1 and FEF25-75 values, with the FEV1 decreasing by 4.55%, and the FEF25-75 decreasing by 4.2% (p < 0.05). In the COPD subgroup of group 2, no significant decrease was observed in the pulmonary function test values (p > 0.05). CONCLUSIONS: This study demonstrated that NAC administration in COPD patients undergoing on-pump coronary artery surgery resulted in the preservation of pulmonary functions.en_US
dc.identifier.endpage187en_US
dc.identifier.issn1128-3602
dc.identifier.issue1en_US
dc.identifier.pmid26813472en_US
dc.identifier.scopus2-s2.0-84958056081en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage180en_US
dc.identifier.urihttps://hdl.handle.net/11616/97172
dc.identifier.volume20en_US
dc.identifier.wosWOS:000369544000029en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectPulmonary function testsen_US
dc.subjectBypass surgeryen_US
dc.subjectCoronary arteryen_US
dc.titleThe effects of N-acetylcysteine on pulmonary functions in patients undergoing on-pump coronary artery surgery: a double blind placebo controlled studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu