Quercetin protection against ciprofloxacin induced liver damage in rats

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dc.authorscopusid55623262400
dc.authorscopusid26867577800
dc.authorscopusid56040001000
dc.authorscopusid7004559930
dc.authorscopusid8729398900
dc.authorscopusid55903323700
dc.contributor.authorTaslidere E.
dc.contributor.authorDogan Z.
dc.contributor.authorElbe H.
dc.contributor.authorVardi N.
dc.contributor.authorCetin A.
dc.contributor.authorTurkoz Y.
dc.date.accessioned2024-08-04T20:00:45Z
dc.date.available2024-08-04T20:00:45Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCiprofloxacin is a common, broad spectrum antibacterial agent; however, evidence is accumulating that ciprofloxacin may cause liver damage. Quercetin is a free radical scavenger and antioxidant. We investigated histological changes in hepatic tissue of rats caused by ciprofloxacin and the effects of quercetin on these changes using histochemical and biochemical methods. We divided 28 adult female Wistar albino rats into four equal groups: control, quercetin treated, ciprofloxacin treated, and ciprofloxacin + quercetin treated. At the end of the experiment, liver samples were processed for light microscopic examination and biochemical measurements. Sections were prepared and stained with hematoxylin and eosin, and a histopathologic damage score was calculated. The sections from the control group appeared normal. Hemorrhage, inflammatory cell infiltration and intracellular vacuolization were observed in the ciprofloxacin group. The histopathological findings were reduced in the group treated with quercetin. Significant differences were found between the control and ciprofloxacin groups, and between the ciprofloxacin and ciprofloxacin + quercetin groups. Quercetin administration reduced liver injury caused by ciprofloxacin in rats. We suggest that quercetin may be useful for preventing ciprofloxacin induced liver damage. © 2015 The Biological Stain Commission.en_US
dc.identifier.doi10.3109/10520295.2015.1085093
dc.identifier.endpage121en_US
dc.identifier.issn1052-0295
dc.identifier.issue2en_US
dc.identifier.pmid26529398en_US
dc.identifier.scopus2-s2.0-84955346733en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage116en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2015.1085093
dc.identifier.urihttps://hdl.handle.net/11616/90956
dc.identifier.volume91en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofBiotechnic and Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectciprofl oxacinen_US
dc.subjectliveren_US
dc.subjectquercetinen_US
dc.subjectraten_US
dc.titleQuercetin protection against ciprofloxacin induced liver damage in ratsen_US
dc.typeArticleen_US

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