Hodgkin's lymphoma associated with paraneoplastic cerebellar degeneration in children: a case report and review of the literature

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dc.authoridARSLAN, MÜJGAN/0000-0002-0486-3431
dc.authoridKılıç, Betül/0000-0003-0884-2635
dc.authoridDalmau, Josep/0000-0001-5856-2813
dc.authorwosidArslan, Müjgan/AAN-5580-2021
dc.authorwosidARSLAN, MÜJGAN/AAN-5584-2021
dc.authorwosidKılıç, Betül/ABS-2287-2022
dc.contributor.authorGungor, Serdal
dc.contributor.authorKilic, Betul
dc.contributor.authorArslan, Mujgan
dc.contributor.authorOzgen, Unsal
dc.contributor.authorDalmau, Josep
dc.date.accessioned2024-08-04T20:42:43Z
dc.date.available2024-08-04T20:42:43Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractParaneoplastic cerebellar degeneration (PCD) can occur severely and appear as subacute cerebellar syndrome. PCD may be associated with small cell lung cancer, adenocarcinoma, breast cancer, ovarian carcinoma, and Hodgkin's lymphoma. An 11-year-old male was admitted with acute cerebellar ataxia, dysarthria, and diplopia. Mediastinal conglomerated lymph nodes were depicted in a chest computed tomography (CT) examination, and diagnosis of stage IV Hodgkin's lymphoma was obtained after a lymph node biopsy. The antibodies against Purkinje cells (anti-Tr antibody) were positive immunohistochemically. Thus, paraneoplastic cerebellar degeneration depending on Hodgkin's disease was diagnosed. Despite the completion of chemotherapy, neurological recovery was not observed in the patient and plasmapheresis with immunoadsorption, and intravenous immunoglobulin (IVIG) was performed. Truncal ataxia, gait disturbance, and tremors decreased. Consequently, we thought that plasmapheresis with the immunoadsorption method and IVIG therapy might be a treatment option for cerebellar ataxia caused by a mechanism of immune ancestry.en_US
dc.description.sponsorshipICREA Funding Source: Customen_US
dc.identifier.doi10.1007/s00381-016-3284-y
dc.identifier.endpage512en_US
dc.identifier.issn0256-7040
dc.identifier.issn1433-0350
dc.identifier.issue3en_US
dc.identifier.pmid27796550en_US
dc.identifier.scopus2-s2.0-84992699723en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage509en_US
dc.identifier.urihttps://doi.org/10.1007/s00381-016-3284-y
dc.identifier.urihttps://hdl.handle.net/11616/97552
dc.identifier.volume33en_US
dc.identifier.wosWOS:000398041500018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofChilds Nervous Systemen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Tr antibodiesen_US
dc.subjectImmunoadsorptionen_US
dc.subjectHodgkin's diseaseen_US
dc.subjectParaneoplastic cerebellar degenerationen_US
dc.titleHodgkin's lymphoma associated with paraneoplastic cerebellar degeneration in children: a case report and review of the literatureen_US
dc.typeReview Articleen_US

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