Is Decorin a Promising New Agent for Facial Nerve Regeneration? An Experimental Study

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dc.authorwosidYiğit, Enes/ABH-1477-2021
dc.contributor.authorCinar, Zehra
dc.contributor.authorEmre, Ufuk
dc.contributor.authorGul, Mehmet
dc.contributor.authorYigit, Ozgar
dc.contributor.authorMammadov, Elshan
dc.contributor.authorYigit, Enes
dc.contributor.authorGul, Semir
dc.date.accessioned2024-08-04T20:49:24Z
dc.date.available2024-08-04T20:49:24Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate the effects of systemic administration of decorin (DC) on facial nerve (FN) regeneration. Methods: A total of 32 female albino Wistar rats were divided into 4 groups: control (C) group: no bilateral FN neurorrhaphy (B-FNN), no DC application, sham-operated group: B-FNN without DC application, DC group: DC application without B-FNN, and B-FNN + DC group: B-FNN and DC application. Nerve conduction studies were performed before and after skin incisions at 1st, 3rd, 5th, and 7th weeks in all groups. The amplitude and latency of compound muscle action potentials were recorded. FN samples were obtained and were investigated under light microscopy and immunohistochemical staining. The nerve and axon diameter, number of axons, H score, Schwann cell proliferation, and myelin and axonal degeneration were recorded quantitatively. Results: In the sham group, the 3rd and 5th postoperative week, amplitude values were significantly lower than those of the B-FNN + DC group (p < 0.05). Nerve diameters were found to be significantly larger in the sham, DC, and B-FNN + DC groups than in the C group (p < 0.05). The number of axons, the axon diameter, and the H scores were found to be significantly higher in the B-FNN + DC group than in the sham group (p < 0.05). The Schwann cell proliferation, myelin degeneration, and axonal degeneration scores were significantly lower in the B-FNN + DC group than in the sham group (p < 0.05). Conclusion: Electrophysiological and histopathological evaluation revealed the potential benefits provided by DC. This agent may increase FN regeneration.en_US
dc.identifier.doi10.1159/000512003
dc.identifier.endpage205en_US
dc.identifier.issn1420-3030
dc.identifier.issn1421-9700
dc.identifier.issue3en_US
dc.identifier.pmid33677432en_US
dc.identifier.scopus2-s2.0-85102624411en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage195en_US
dc.identifier.urihttps://doi.org/10.1159/000512003
dc.identifier.urihttps://hdl.handle.net/11616/99823
dc.identifier.volume26en_US
dc.identifier.wosWOS:000627432100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofAudiology and Neuro-Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFacial nerveen_US
dc.subjectAxotomyen_US
dc.subjectNeurorrhaphyen_US
dc.subjectCompound muscle action potentialen_US
dc.subjectDecorinen_US
dc.titleIs Decorin a Promising New Agent for Facial Nerve Regeneration? An Experimental Studyen_US
dc.typeArticleen_US

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