Pre- and Post-Natal Endotoxin Exposures: Effects on Leucocyte Ratios and Levels of IL-1?, TNF-, Gonadotropins and Corticosterone in Female Rats

Basit Öğe Kaydı
dc.contributor.authorYıldız, Sedat
dc.contributor.authorUcar, Cihat
dc.date.accessioned2024-08-04T19:53:16Z
dc.date.available2024-08-04T19:53:16Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The aim of this study is to investigate the long-term effects of prenatal and postnatal endotoxin exposure on hematological parameters, blood cytokines (TNF-?, IL-1?), gonadotropins and corticosterone levels in female rats. Material and Method: Pregnant rats were injected intraperitoneally sterile saline (SF) or endotoxin (LPS) on days 17-18 of pregnancy. Following birth, female pups were subdivided into two groups and injected either sterile saline (SF, n=17) or endotoxin (LPS, n=17) on postnatal day 60 and four experimental groups were formed (SF+SF, SF+LPS, LPS+SF and LPS+LPS). Blood samples were taken 4 hours after final injection. Plasma levels of IL-1?, TNF-?, corticosteron, LH, FSH and blood leucocyte ratios were evaluated.Results: Neutrophil % ratio was higher but lymphocyte % ratio was lower in SF+LPS, LPS+SF and LPS+LPS groups than SF+SF group. Corticosterone, LH and FSH levels were not different between the groups but TNF-? level of LPS+LPS groups was higher than SF+SF and LPS+SF groups. IL-1? level of SF+LPS group was higher than SF+SF and LPS+SF groups. Conclusion: The results suggest that prenatal and post-pubertal endotoxin exposure programs cytokine level neutrophil and lymphocyte percentages without affecting hypothalamo-pituitary-adrenal and –gonadal axes.en_US
dc.identifier.doi10.37990/medr.891293
dc.identifier.endpage244en_US
dc.identifier.issn2687-4555
dc.identifier.issue3en_US
dc.identifier.startpage239en_US
dc.identifier.trdizinid1125040en_US
dc.identifier.urihttps://doi.org/10.37990/medr.891293
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1125040
dc.identifier.urihttps://hdl.handle.net/11616/89619
dc.identifier.volume3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedical records-international medical journal (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePre- and Post-Natal Endotoxin Exposures: Effects on Leucocyte Ratios and Levels of IL-1?, TNF-, Gonadotropins and Corticosterone in Female Ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu