Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid

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dc.authoridYakıncı, Mehmet Cengiz/0000-0001-5930-4269
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authorwosidÖZEROL, ELİF/AAA-6707-2021
dc.authorwosidYakıncı, Mehmet Cengiz/ABI-7519-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.contributor.authorKarabiber, H
dc.contributor.authorSommezgoz, E
dc.contributor.authorOzerol, E
dc.contributor.authorYakinci, C
dc.contributor.authorOtlu, B
dc.contributor.authorYologlu, S
dc.date.accessioned2024-08-04T20:13:17Z
dc.date.available2024-08-04T20:13:17Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHomocysteine (HMC) is a sulfur containing amino acid, which plays a role in methionine metabolism. Folic acid (FA) and vitamin B12 (B12) are essential for remethylization of HMC to methionine. HMC level increases in the deficiency of these vitamins. Hyperhomocysteinemia causes vascular endothelial damage, which causes atherosclerosis. The aim of this study is to investigate the effect of valproate (VA) and carbamazepine (CBZ) on the serum levels of HMC, B12, and FA. Thirty-six children receiving CBZ and 30 children receiving VA for epilepsy for the last 1-year period and 29 healthy children as control were the population of this study. After 6 h of fasting serum HMC, B12, and FA levels were measured and results were compared statistically. Mean values of HMC, FA, and B12 levels in control group were 9.2 +/- 2.7 mumol/l, 9.0 +/- 2.0 ng/ml, and 342 +/- 162 pg/ml, in VA group 14.0 +/- 6.8 mumol/l, 7.3 +/- 2.9 ng/ml, and 368 +/- 159 pg/ml, in CBZ group 16.0 +/- 13.1 mumol/l, 7.5 +/- 3.3 ng/ml, and 285 +/- 158 pg/ml, respectively. Serum HMC levels were higher in VA and CBZ groups than control group (P < 0.01 and P < 0.05, respectively). Serum FA levels were lower in VA and CBZ groups compared to control group (P < 0.05). Serum levels of B12 were not different between VA and control groups (P > 0.05). In CBZ group serum B 12 levels were lower than control group (P < 0.05). FA may be added to the treatment protocol (if the patients take only CBZ, then B 12 should also be added) for patients taking these antiepileptic drugs to decrease the degenerative effect of VA and CBZ on vascular endothelium. (C) 2002 Elsevier Science B.V. All rights reserved.en_US
dc.identifier.doi10.1016/S0387-7604(02)00163-8
dc.identifier.endpage115en_US
dc.identifier.issn0387-7604
dc.identifier.issue2en_US
dc.identifier.pmid12581807en_US
dc.identifier.scopus2-s2.0-0037360131en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1016/S0387-7604(02)00163-8
dc.identifier.urihttps://hdl.handle.net/11616/93499
dc.identifier.volume25en_US
dc.identifier.wosWOS:000181300200005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBrain & Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthomocysteineen_US
dc.subjectsodium valproateen_US
dc.subjectcarbamazepineen_US
dc.subjectfolic aciden_US
dc.subjectvitamin B12en_US
dc.titleEffects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic aciden_US
dc.typeArticleen_US

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