Investigation of the Effect of Milrinone on Renal Damage in an Experimental Non-Heart Beating Donor Model

Basit Öğe Kaydı
dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authoridUyumlu, Ayşe Burçin/0000-0001-9517-9274
dc.authoridkaradağ, mehmet/0000-0001-9539-4193
dc.authoridsaygili, eyup ilker/0000-0002-0102-4237
dc.authoridkaradağ, mehmet/0000-0001-9539-4193
dc.authoridCEYLAN, Seyit Mehmet/0000-0002-8908-3345
dc.authorwosidKazımoğlu, Hatem/JFK-9795-2023
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosidUyumlu, Ayşe Burçin/ABH-5573-2020
dc.authorwosidkaradağ, mehmet/AFE-8117-2022
dc.authorwosidsaygili, eyup ilker/X-1954-2019
dc.authorwosidkaradağ, mehmet/AAE-9646-2022
dc.contributor.authorUysal, Erdal
dc.contributor.authorDokur, Mehmet
dc.contributor.authorAltinay, Serdar
dc.contributor.authorSaygili, Eyup Ilker
dc.contributor.authorBatcioglu, Kadir
dc.contributor.authorCeylan, Mehmet S.
dc.contributor.authorKazimoglu, Hatem
dc.date.accessioned2024-08-04T20:43:16Z
dc.date.available2024-08-04T20:43:16Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: In our study, it was aimed to investigate the preventive effect of milrinone on renal damage in experimental controlled non-heart-beating donors (NHBDs) model. Materials and Methods: Sixteen rats randomly divided into 2 groups, 8 rats in each were used. Group 1 was control, group 2 was milrinone group. Group 1 rats received 1.25ml 0.09% NaCl intraperitoneally equivalent to the milrinone diluted volume. Group 2 rats were administered intraperitoneally with 0.5mg/kg of milrinone 2hours before cardiac arrest. After the cardiac arrest, left nephrectomy was applied to the rats. Malondialdehyde, superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) activities, Caspase-3 (apoptotic index) and histopathological evaluation were performed in the tissues. Results: In the milrinone group, the total injury score was significantly lower relative to the control group (p = 0.001). Caspase-3 staining was moderately strong in the control group but weaker in the milrinone group. Apoptotic index was significantly lower in the milrinone group compared to the control group (p = 0.001). In comparison between groups, SOD and GPx in the milrinone group was significantly higher than the control group (p = 0.008, p = 0.006). Conclusions: Milrinone has been shown to be effective in the prevention of tissue damage due to oxidative stress and inflammatory process in the renal of warm ischemia in the experimental NHBDs model and in protecting the renal. Milrinone increases antioxidant activity while reducing apoptosis. Systemic administration of milrinone prior to cardiac arrest may be beneficial. Administration of milrinone to the recipient in the perioperative period may contribute to donor function.en_US
dc.identifier.doi10.1080/08941939.2017.1343880
dc.identifier.endpage411en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue5en_US
dc.identifier.pmid28708967en_US
dc.identifier.scopus2-s2.0-85023766870en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage402en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2017.1343880
dc.identifier.urihttps://hdl.handle.net/11616/97891
dc.identifier.volume31en_US
dc.identifier.wosWOS:000460144500008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKidneyen_US
dc.subjecttransplantationen_US
dc.subjectischemia-reperfusionen_US
dc.subjectapoptosisen_US
dc.subjectmilrinoneen_US
dc.subjectraten_US
dc.titleInvestigation of the Effect of Milrinone on Renal Damage in an Experimental Non-Heart Beating Donor Modelen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu