Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.contributor.authorParlakpinar, H
dc.contributor.authorTasdemir, S
dc.contributor.authorPolat, A
dc.contributor.authorBay-Karabulut, A
dc.contributor.authorVardi, N
dc.contributor.authorUcar, M
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:13:38Z
dc.date.available2024-08-04T20:13:38Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe toxicity of gentamicin (GEN) in the kidney seems to relate to the generation of reactive oxygen species (ROS). Caffeic acid phenethyl ester (CAPE) has been demonstrated to have antioxidant, free radical scavenger and anti-inflammatory effects. It has been proposed that antioxidant maintain the concentration of reduced glutathione (GSH) may restore the cellular defense mechanisms and block lipid peroxidation thus protect against the toxicity of wide variety of nephrotoxic chemicals. We investigated the effects of CAPE on GEN-induced changes in renal malondialdehyde (MDA), a lipid peroxidation product, nitric oxide (NO) generation, superoxide dismutase (SOD), catalase (CAT) activities, GSH content, blood urea nitrogen (BUN) and serum creatinine (Cr) levels. Morphological changes in the kidney were also examined. A total of 32 rats were equally divided into four groups which were: (1) control, (2) injected with intraperitoneally (i.p.) GEN, (3) injected with i.p. GEN + CAPE and (4) injected with i.p. CAPE. GEN administration to control rats increased renal MDA and NO generation but decreased SOD and CAT activities, and GSH content. CAPE administration with GEN injections caused significantly decreased MDA, NO generation and increased SOD, CAT activities and GSH content when compared with GEN alone. Serum level of BUN and Cr significantly increased as a result of nephrotoxicity. CAPE also, significantly decreased serum BUN and Cr levels. Morphological changes in the kidney due to GEN, including tubular necrosis, were evaluated qualitatively. In addition, CAPE reduced the degree of kidney tissue damage induced by GEN. Both biochemical findings and histopathological evidence showed that administration of CAPE reduced the GEN-induced kidney damage. Our results indicated that CAPE acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GEN both at the biochemical and histological level. Thus, CAPE could be effectively combined with GEN treatment. (C) 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.tox.2004.08.024
dc.identifier.endpage177en_US
dc.identifier.issn0300-483X
dc.identifier.issn1879-3185
dc.identifier.issue2en_US
dc.identifier.pmid15596248en_US
dc.identifier.scopus2-s2.0-10444235127en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage169en_US
dc.identifier.urihttps://doi.org/10.1016/j.tox.2004.08.024
dc.identifier.urihttps://hdl.handle.net/11616/93757
dc.identifier.volume207en_US
dc.identifier.wosWOS:000226645500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofToxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectgentamicinen_US
dc.subjectreactive oxygen radicalsen_US
dc.subjectrenal toxicityen_US
dc.subjectraten_US
dc.titleProtective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in ratsen_US
dc.typeArticleen_US

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