Acyclovir-induced nephrotoxicity and neurotoxicity in a case of viral encephalitis: a case report

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dc.contributor.authorDertli, Bulent
dc.contributor.authorGuzel Karahan, Sena
dc.contributor.authorKoseoglu, Kadir
dc.contributor.authorCakir, Ahmet
dc.contributor.authorSalduz, Ekrem
dc.date.accessioned2026-04-04T13:33:18Z
dc.date.available2026-04-04T13:33:18Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractViral encephalitis is a hazardous central nervous system disorder requiring immediate antiviral intervention. Acyclovir is the standard treatment for herpes simplex virus (HSV) encephalitis; nevertheless, improper dosing or administration can lead to nephrotoxicity and neurotoxicity. This case describes a 54-year-old male patient admitted for an allergic reaction, who thereafter had incoherent speech, instability and involuntary motions suggestive of HSV encephalitis. Intravenous acyclovir treatment was initiated empirically following cerebrospinal fluid examination. On the third day of therapy, the patient exhibited acute renal impairment, accompanied by hallucinations and significant psychomotor agitation. Following the clinical pharmacist's recommendations, the dosage was adjusted and the infusion period was prolonged to at least 1 hour, predicated on an estimated glomerular filtration rate of 20 mL/min/1,73 m(2). Subsequent to these surgeries, renal function and neurological status steadily enhanced, enabling a successful resolution of treatment. This example highlights the crucial role of clinical pharmacists in reducing acyclovir-related toxicities via personalised dosage and infusion management.
dc.identifier.doi10.1136/ejhpharm-2025-004705
dc.identifier.issn2047-9956
dc.identifier.issn2047-9964
dc.identifier.orcid0009-0001-5856-6723
dc.identifier.pmid41475795
dc.identifier.scopus2-s2.0-105027390105
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1136/ejhpharm-2025-004705
dc.identifier.urihttps://hdl.handle.net/11616/109066
dc.identifier.wosWOS:001655698500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmj Publishing Group
dc.relation.ispartofEuropean Journal of Hospital Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectAcyclovir
dc.subjectcase report
dc.subjectDRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS
dc.subjectAcute Kidney Injury
dc.subjectNeuropathology
dc.titleAcyclovir-induced nephrotoxicity and neurotoxicity in a case of viral encephalitis: a case report
dc.typeArticle

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