Effects of ketofol and propofol on intubation conditions and hemodynamics without the use of neuromuscular blockers in patients undergoing tympanomastoidectomy

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dc.contributor.authorDemiroz Aslan, Duygu
dc.contributor.authorUcar, Muharrem
dc.contributor.authorErdogan, Mehmet Ali
dc.contributor.authorSanli, Mukadder
dc.contributor.authorGulhas, Nurcin
dc.contributor.authorÇolak, Cemil
dc.contributor.authorDurmus, Mahmut
dc.date.accessioned2021-05-22T17:30:11Z
dc.date.available2021-05-22T17:30:11Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract: The effect of ketofol, a mixture of ketamine and propofol in various ratios, on hemodynamic, for intubation without the use of neuromuscular blockers, has not been elucidated in patients undergoing tympanomastoidectomy. We evaluated the effects of ketofol and propofol on intubation conditions and hemodynamic without the use of a neuromuscular blocker. The prospective randomized, double-blinded study was scheduled for tympanoplasty or mastoidectomy. The patients were divided randomly into a propofol group (Group P) and a ketofol group (Group KP). Intubation conditions, changes in hemodynamics, HR, MAP, systolic arterial pressure (SAP), and SpO2 values were recorded before induction, after induction, after intubation, and at 3-min intervals during the first 30 min, 5-min intervals for the next 30 min, and 10-min intervals after that. In the intragroup evaluation, SAP, DAP, MAP and HR values were lower in both groups compared to the baseline values. Hemodynamic values were significantly lower in Group P than in Group KP after intubation compared to baseline. DAP at 12 and 18 min, DAP and MAP at 24 min, SAP, DAP and MAP at 27 min, and SAP and MAP at 30 min after the start of the operation were significantly lower in Group P than in Group KP. The need for ephedrine and the number of patients who required ephedrine were significantly lower in Group KP than in Group P. Ketofol provided appropriate intubation conditions similar to propofol, without the use of a neuromuscular blocker, and contributed to better hemodynamic conditions in patients undergoing tympanomastoidectomy.en_US
dc.identifier.citationASLAN D. D,UCAR M,ERDOGAN M. A,SANLİ M,GULHAS N,ÇOLAK C,DURMUS M (2019). Effects of ketofol and propofol on intubation conditions and hemodynamics without the use of neuromuscular blockers in patients undergoing tympanomastoidectomy. Medicine Science, 8(2), 381 - 384. Doi: doi: 10.5455/medscience.2019.08.9042en_US
dc.identifier.doi10.5455/medscience.2019.08.9042en_US
dc.identifier.endpage384en_US
dc.identifier.issn2147-0634
dc.identifier.issue2en_US
dc.identifier.startpage381en_US
dc.identifier.trdizinid371796en_US
dc.identifier.urihttps://doi.org/10.5455/medscience.2019.08.9042
dc.identifier.urihttps://hdl.handle.net/11616/33647
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/371796
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.relation.ispartofMedicine Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffects of ketofol and propofol on intubation conditions and hemodynamics without the use of neuromuscular blockers in patients undergoing tympanomastoidectomyen_US
dc.typeArticleen_US

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