Serum levels of soluble P-selectin are increased and associated with disease activity in patients with Behcet's syndrome

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720;
dc.authorwosidEvereklioğlu, Cem/A-5370-2018
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidBORLU, MURAT/U-1593-2019
dc.authorwosidÖzerol, İbrahim Halil/ABI-8015-2020
dc.contributor.authorTurkoz, Y
dc.contributor.authorEvereklioglu, C
dc.contributor.authorÖzkiris, A
dc.contributor.authorMistik, S
dc.contributor.authorBorlu, M
dc.contributor.authorÖzerol, IH
dc.contributor.authorDuygulu, F
dc.date.accessioned2024-08-04T20:15:02Z
dc.date.available2024-08-04T20:15:02Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBehcet's syndrome (BS) is a relapsing, chronic, inflammatory disease characterized by endothelial dysfunction, atherothromboembogenesis, and leukocytoclastic vasculitis with complex immunologic molecular interactions. Generalized derangements of the lymphocyte and neutrophil Populations, activated monocytes, and increased PMNLs motility with upregulated cell surface Molecules such as ICAM-1, VCAM-1, and E-selectin, which are found on the endothelial cells, leukocytes, and platelets, have all been demonstrated during the Course of BS. Our aim is to investigate the association of serum concentrations of soluble P-selectin in patients with BS, and to evaluate whether disease activity has an effect on their blood levels. This multicenter study included 31 patients with BS (15 men and 16 women) and 20 age- and sex-matched health), control volunteers (11 men and nine women). Neutrophil count, erythrocyte sedimentation rate, and acute-phase reactants as well as soluble P-selectin levels were determined. The mean age and sex distributions were similar (P>.05) between BS patients (35 years) and control volunteers (36 years). Serum levels of soluble P-selectin in patients with BS (399 +/- 72 ng/mL) were significantly (P<.001) higher when compared with control subjects (164 +/- 40 ng/mL). In addition, active BS patients (453 37 ng/mL) had significantly (P<.001) elevated levels of soluble P-selectin than those in inactive period (341 +/- 52 ng/mL). This study clearly demonstrated that serum Soluble P-selectin levels are increased in BS patients when compared with control Subjects, Suggesting a modulator role for soluble P-selectin during the Course of platelet activation and therefore, atherothrombogenesis formation in BS, especially in active disease.en_US
dc.identifier.doi10.1155/MI.2005.237
dc.identifier.endpage241en_US
dc.identifier.issn0962-9351
dc.identifier.issn1466-1861
dc.identifier.issue4en_US
dc.identifier.pmid16192675en_US
dc.identifier.scopus2-s2.0-25644459869en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage237en_US
dc.identifier.urihttps://doi.org/10.1155/MI.2005.237
dc.identifier.urihttps://hdl.handle.net/11616/94117
dc.identifier.wosWOS:000233728300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofMediators of Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Myocardial-Infarctionen_US
dc.subjectAdhesion Moleculesen_US
dc.subjectPlasma-Levelsen_US
dc.subjectThrombomodulinen_US
dc.subjectReceptoren_US
dc.subjectInflammationen_US
dc.subjectExpressionen_US
dc.subjectPlateletsen_US
dc.subjectProteinen_US
dc.subjectAlphaen_US
dc.titleSerum levels of soluble P-selectin are increased and associated with disease activity in patients with Behcet's syndromeen_US
dc.typeArticleen_US

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