The effect of lycopene on hepatotoxicity of aflatoxin B1 in rats

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dc.authoridYilmaz, Seval/0000-0002-2040-9247
dc.authorwosidKISAÇAM, Mehmet Ali/C-6114-2018
dc.authorwosidKaya, Emre/JAO-0316-2023
dc.authorwosidKaya, Emre/V-8939-2018
dc.contributor.authorKaraca, Aysegul
dc.contributor.authorYilmaz, Seval
dc.contributor.authorKaya, Emre
dc.contributor.authorAltun, Serdar
dc.date.accessioned2024-08-04T20:46:44Z
dc.date.available2024-08-04T20:46:44Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOxidative damage caused by aflatoxin (AF) in rat liver tissue and the inhibition effect of lycopene against this injury was investigated. Groups were formed as; control group (not treated), lycopene group (5 mg/kg/day, gavage for 15 days), AFB1 group (0.5 mg/kg/day, gavage for 7 days) and AFB1 + lycopene group. Lycopene administered simultaneously with AFB1. It was observed significant increase in malondialdehyde level, decrease in glutathione level, antioxidant enzyme activities in liver tissue of AFB1 group when compared with control group. It was determined to significantly increase in plasma aspartate transaminase, alanine transaminase, lactate dehydrogenase activities in AFB1 group when compared with control group. It was determined significant decrease in malondialdehyde level, plasma aspartate transaminase, alanine transaminase, lactate dehydrogenase activities and increase in glutathione level, antioxidant enzyme activities in AFB1 + lycopene group when compared with AFB1 group. This study suggests that lycopene which has antioxidant properties can be prevented from AFB1 induced hepatotoxicity.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Firat University [14.02]en_US
dc.description.sponsorshipThis work was funded by Scientific Research Projects Coordination Unit of Firat University, Grant/Award Number: VF. 14.02.en_US
dc.identifier.doi10.1080/13813455.2019.1648516
dc.identifier.endpage436en_US
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue5en_US
dc.identifier.pmid31378089en_US
dc.identifier.scopus2-s2.0-85070456848en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage429en_US
dc.identifier.urihttps://doi.org/10.1080/13813455.2019.1648516
dc.identifier.urihttps://hdl.handle.net/11616/98906
dc.identifier.volume127en_US
dc.identifier.wosWOS:000479159500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAflatoxinen_US
dc.subjectantioxidant enzymeen_US
dc.subjectglutathioneen_US
dc.subjectlycopeneen_US
dc.subjectmalondialdehydeen_US
dc.titleThe effect of lycopene on hepatotoxicity of aflatoxin B1 in ratsen_US
dc.typeArticleen_US

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