The effects of pentoxifylline and caffeic acid phenethyl ester in the treatment of d-galactosamine-induced acute hepatitis in rats

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dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridTaskapan, Mehmet Cagatay/0000-0002-5273-4909
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidTaskapan, Mehmet Cagatay/ABI-7747-2020
dc.contributor.authorTaslidere, E.
dc.contributor.authorVardi, N.
dc.contributor.authorEsrefoglu, M.
dc.contributor.authorAtes, B.
dc.contributor.authorTaskapan, C.
dc.contributor.authorYologlu, S.
dc.date.accessioned2024-08-04T20:41:36Z
dc.date.available2024-08-04T20:41:36Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate histological changes in hepatic tissue and effects of pentoxifylline (PTX) and caffeic acid phenethyl ester (CAPE) on these changes using histochemical and biochemical methods in rats, in which hepatitis was established by d-galactosamine (d-GAL). Rats were divided into five groups as follows: control group, d-GAL (24 h) group, d-GAL group, d-GAL + PTX group, and d-GAL + CAPE group. In histological evaluations, the control group showed normal appearance of the liver cells. However in the d-GAL groups, focal areas consisting of inflammatory, necrotic, and apoptotic cells were detected in parenchyma. Glycogen loss was observed in the hepatocytes localized at the periphery of lobule. It was found that number of mast cells of portal areas were significantly higher in d-GAL groups compared with other groups (p = 0.0001). In addition, the number of cells with positive staining by Ki-67 and caspase-3 were significantly increased in GAL groups compared with the control group (p = 0.0001). In biochemical analysis, there was an increase in malondialdehyde and myeloperoxidase levels, while a decrease was observed in glutathione level and glutathione peroxidase activity in groups treated with d-GAL compared with the control group. On the other hand, it was seen that, in the groups treated with d-GAL, histological and biochemical injuries in the liver were reduced by administration of PTX and CAPE. In this study, we demonstrated the ameliorative effects of PTX and CAPE on d-GAL-induced liver injury.en_US
dc.description.sponsorshipScientific Research Fund of Inonu University [2011/55]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was financially supported by a grant from Scientific Research Fund of Inonu University (grant number: 2011/55).en_US
dc.identifier.doi10.1177/0960327115586820
dc.identifier.endpage365en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue4en_US
dc.identifier.pmid25977259en_US
dc.identifier.scopus2-s2.0-84960814654en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage353en_US
dc.identifier.urihttps://doi.org/10.1177/0960327115586820
dc.identifier.urihttps://hdl.handle.net/11616/97223
dc.identifier.volume35en_US
dc.identifier.wosWOS:000372813500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatitisen_US
dc.subjectd-galactosamineen_US
dc.subjectpentoxifyllineen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.titleThe effects of pentoxifylline and caffeic acid phenethyl ester in the treatment of d-galactosamine-induced acute hepatitis in ratsen_US
dc.typeArticleen_US

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