The relationship between trough drug concentrations and ductal closure in preterm infants treated with three-dose-oral ibuprofen

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dc.authoridOncel, Mehmet Yekta/0000-0003-0760-0773
dc.authoridERDEVE, OMER/0000-0002-3193-0812
dc.authorwosidERDEVE, Omer/W-1480-2017
dc.authorwosidOncel, Mehmet Yekta/L-5664-2013
dc.contributor.authorYurttutan, Sadik
dc.contributor.authorErdeve, Omer
dc.contributor.authorOncel, Mehmet Yekta
dc.contributor.authorOzdemir, Ramazan
dc.contributor.authorDilmen, Ugur
dc.date.accessioned2024-08-04T20:37:45Z
dc.date.available2024-08-04T20:37:45Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study was to characterize the pharmacokinetic profile of oral ibuprofen on consecutive 3 d by trough serum levels, and if possible to define a cut-off level for ductal closure in preterm infants. The study enrolled 20 preterm infants with gestational age <= 30 weeks, birth weight <1250 g and hemodynamically significant patent ductus arteriosus (hsPDA). Patients received oral ibuprofen at an initial dose of 10 mg/kg, followed by 5 mg/kg at 24 and 48 h. Patients were compared for serum ibuprofen levels in addition to their demographic and clinical data in case of their response to the treatment. hsPDA closed in 16 (80%) of the patients. Although mean ibuprofen levels on consecutive 3 d showed a plateau in general, ibuprofen serum levels on the first treatment day were statistically low in patients with unclosed hsPDA (p = 0.003). The optimal cut-off value for serum ibuprofen level on the first treatment day was measured as 5.5 mg/l with 100% sensitivity and 93% specificity. Serum ibuprofen level on the first treatment day seems to be an important factor for a successful ductal closure. Target concentration approach by the evaluation of trough level may be applicable to real-time dosing strategy.en_US
dc.identifier.doi10.3109/14767058.2013.784739
dc.identifier.endpage1310en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue13en_US
dc.identifier.pmid23488980en_US
dc.identifier.scopus2-s2.0-84881159673en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1306en_US
dc.identifier.urihttps://doi.org/10.3109/14767058.2013.784739
dc.identifier.urihttps://hdl.handle.net/11616/96161
dc.identifier.volume26en_US
dc.identifier.wosWOS:000322650600011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConcentrationen_US
dc.subjectibuprofenen_US
dc.subjectoralen_US
dc.subjectpatent ductus arteriosusen_US
dc.subjectpharmacokineticsen_US
dc.subjectpretermen_US
dc.titleThe relationship between trough drug concentrations and ductal closure in preterm infants treated with three-dose-oral ibuprofenen_US
dc.typeArticleen_US

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