Neuroprotection against ccl4 induced brain damage with crocin in wistar rats

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dc.contributor.authorAltinoz, E
dc.contributor.authorErdemli, ME
dc.contributor.authorGül, M.
dc.contributor.authorAksungur, Z
dc.contributor.authorGül, S
dc.contributor.authorÇanta, HG
dc.contributor.authorKaya, GB
dc.contributor.authorTurkoz, Y
dc.date.accessioned2019-06-20T11:00:09Z
dc.date.available2019-06-20T11:00:09Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOwing to its lipophilic property, carbon tetrachloride (CCl4) is rapidly absorbed by both the liver and brain. We investigated the protective effects of crocin against brain damage caused by CCl4. Fifty rats were divided into five groups of ten: control, corn oil, crocin, CCl4 and CCl4 + crocin. CCl4 administration decreased glutathione (GSH) and total antioxidant status (TAS) levels, and catalase (CAT) activity, while significant increases were observed in malondialdehyde (MDA) and total oxidant status (TOS) levels and superoxide dismutase (SOD) activity. The cerebral cortex nuclear lamina developed a spongy appearance, neuronal degeneration was observed in the hippocampus, and heterochromatic and pyknotic neurons with increased cytoplasmic eosinophilia were observed in the hippocampus after CCl4 treatment. Because crocin exhibits strong antioxidant properties, crocin treatment increased GSH and TAS levels and CAT activities, and decreased MDA and TOS levels and SOD activity; significant improvements also were observed in histologic architecture. We found that crocin administration nearly eliminated CCl4 induced brain damage by preventing oxidative stress.en_US
dc.identifier.citationAltinoz, E . Erdemli, ME .Gül, M. Aksungur, Z .Gül, S.Çanta, HG .Kaya, GB.Turkoz, Y .(2018).Neuroprotection against ccl4 induced brain damage with crocin in wistar rats.Cilt:93. Sayı:8. 623-631ss.en_US
dc.identifier.doi10.1080/10520295.2018.1519725en_US
dc.identifier.endpage631en_US
dc.identifier.issue8en_US
dc.identifier.startpage623en_US
dc.identifier.urihttps://hdl.handle.net/11616/11896
dc.identifier.volume93en_US
dc.language.isoenen_US
dc.publisherBıotechnıc & hıstochemıstryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInduced Oxıdatıve Stressen_US
dc.subjectTotal Antıoxıdant Capacıtyen_US
dc.subjectCarbon-Tetrachlorıdeen_US
dc.subjectHepatoprotectıve Propertıesen_US
dc.subjectInduced Toxıcıtyen_US
dc.subjectFree-Radıcalsen_US
dc.subjectInjuryen_US
dc.subjectProtectıonen_US
dc.subjectExtracten_US
dc.subjectEthanolen_US
dc.titleNeuroprotection against ccl4 induced brain damage with crocin in wistar ratsen_US
dc.typeArticleen_US

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