Quantitative evaluation of brain involvement in ataxia telangiectasia by diffusion weighted MR imaging

Basit Öğe Kaydı
dc.authoridYakıncı, Mehmet Cengiz/0000-0001-5930-4269
dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.authorwosidYakıncı, Mehmet Cengiz/ABI-7519-2020
dc.contributor.authorFirat, AK
dc.contributor.authorKarakas, HM
dc.contributor.authorFirat, Y
dc.contributor.authorYakinci, C
dc.date.accessioned2024-08-04T20:15:03Z
dc.date.available2024-08-04T20:15:03Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To evaluate the value of diffusion weighted imaging (DWI) in diagnosing ataxia telangiectasia (AT) and to investigate the spatial distribution of cerebral microstructural changes caused by the disease. Methods: Six AT patients (9-13 years) and nine healthy control subjects were examined on 1.5 T scanner. In addition to conventional MR images, DWI were performed with a fat suppressed, multishot spin echo EPI sequence using B values of 0, 500 and 1000 s/mm(2). Mean ADC values were measured from 16 different supra and infratentorial location. The difference between controls and AT patients regarding ADC values, and the accuracy, sensitivity and specificity of them in discrimination were analyzed with t-tests, logistic regression analysis, ANOVA and ROC curves. Results: Conventional images of the controls were normal. In AT patients, the only conventional MR abnormality was cerebellar atrophy. The difference between both groups regarding mean ADC values was not significant for any of the cerebral structures. In contrary to cerebrum, cerebellar mean ADC values of patients and controls were statistically different (p < 0.011-0.0001). Patients and controls were classified with 100% accuracy using ADC values of cerebellar white matter and cortex together (p < 0.016). The cut-off ADC value (0.699 mm(2)/s) for middle cerebellar cortex had produced highest (100%) sensitivity and specificity. There was a difference between superior, middle and inferior cerebellar cortex regarding ADC values (p < 0.026). Superior cerebellar cortex (0.987 +/- 0.1956 mm(2)/s) had higher ADC values than the middle and inferior cerebellar cortex. Conclusion: DWI provides a supplementary and objective imaging finding in AT. This finding is highly accurate in the radiological discrimination of healthy subjects and AT. Our findings also implicate that AT causes a diffuse atrophy and mostly affects superior part of the cortex. (C) 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejrad.2005.04.009
dc.identifier.endpage196en_US
dc.identifier.issn0720-048X
dc.identifier.issn1872-7727
dc.identifier.issue2en_US
dc.identifier.pmid15908154en_US
dc.identifier.scopus2-s2.0-26944503047en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage192en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejrad.2005.04.009
dc.identifier.urihttps://hdl.handle.net/11616/94144
dc.identifier.volume56en_US
dc.identifier.wosWOS:000233267400011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofEuropean Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapparent diffusion coefficienten_US
dc.subjectataxia telangiectasiaen_US
dc.subjectdiffusion weighted imagingen_US
dc.subjectmagnetic resonance imagingen_US
dc.titleQuantitative evaluation of brain involvement in ataxia telangiectasia by diffusion weighted MR imagingen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu